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ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome.
Vanhauwaert R, Oury J, Vankerckhoven B, Steyaert C, Jensen SM, Vergoossen DLE, Kneip C, Santana L, Lim JL, Plomp JJ, Augustinus R, Koide S, Blanchetot C, Ulrichts P, Huijbers MG, Silence K, Burden SJ. Vanhauwaert R, et al. Among authors: vergoossen dle. Sci Transl Med. 2024 Sep 18;16(765):eado7189. doi: 10.1126/scitranslmed.ado7189. Epub 2024 Sep 18. Sci Transl Med. 2024. PMID: 39292800
Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.
Oury J, Gamallo-Lana B, Santana L, Steyaert C, Vergoossen DLE, Mar AC, Vankerckhoven B, Silence K, Vanhauwaert R, Huijbers MG, Burden SJ. Oury J, et al. Among authors: vergoossen dle. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2408324121. doi: 10.1073/pnas.2408324121. Epub 2024 Sep 17. Proc Natl Acad Sci U S A. 2024. PMID: 39288173 Free PMC article.
Development and characterization of agonistic antibodies targeting the Ig-like 1 domain of MuSK.
Lim JL, Augustinus R, Plomp JJ, Roya-Kouchaki K, Vergoossen DLE, Fillié-Grijpma Y, Struijk J, Thomas R, Salvatori D, Steyaert C, Blanchetot C, Vanhauwaert R, Silence K, van der Maarel SM, Verschuuren JJ, Huijbers MG. Lim JL, et al. Among authors: vergoossen dle. Sci Rep. 2023 May 8;13(1):7478. doi: 10.1038/s41598-023-32641-1. Sci Rep. 2023. PMID: 37156800 Free PMC article.
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.
Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R. Bogetofte H, et al. Among authors: vergoossen dle. Cell Rep. 2023 Mar 28;42(3):112180. doi: 10.1016/j.celrep.2023.112180. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36870058 Free article.
Enrichment of serum IgG4 in MuSK myasthenia gravis patients.
Vergoossen DLE, Ruiter AM, Keene KR, Niks EH, Tannemaat MR, Strijbos E, Lipka AF, van der Zijde ECJ, van Tol MJD, Bakker JA, Wevers BA, Westerberg E, Borges LS, Tong OC, Richman DP, Illa I, Punga AR, Evoli A, van der Maarel SM, Verschuuren JJ, Huijbers MG. Vergoossen DLE, et al. J Neuroimmunol. 2022 Dec 15;373:577978. doi: 10.1016/j.jneuroim.2022.577978. Epub 2022 Oct 7. J Neuroimmunol. 2022. PMID: 36240543 Free article.
Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis.
Vergoossen DLE, Plomp JJ, Gstöttner C, Fillié-Grijpma YE, Augustinus R, Verpalen R, Wuhrer M, Parren PWHI, Dominguez-Vega E, van der Maarel SM, Verschuuren JJ, Huijbers MG. Vergoossen DLE, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2020635118. doi: 10.1073/pnas.2020635118. Proc Natl Acad Sci U S A. 2021. PMID: 33753489 Free PMC article.
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