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The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host.
Bexkens ML, Martin OMF, van den Heuvel JM, Schmitz MGJ, Teusink B, Bakker BM, van Hellemond JJ, Haanstra JR, Walkinshaw MD, Tielens AGM. Bexkens ML, et al. Among authors: walkinshaw md. Int J Parasitol. 2024 Jun;54(7):367-378. doi: 10.1016/j.ijpara.2024.03.005. Epub 2024 Mar 15. Int J Parasitol. 2024. PMID: 38492780 Free article.
Corneal Graft Rejection: Is it Reflected in Peripheral Immune Cells? Results of a Prospective Multicenter Study (VISICORT).
Vabres B, Pleyer U, Hjortdal J, Murphy CC, Armitage WJ, Imrie L, Cadoux M, Danger R, Bylesjo M, Mac Gabhann P, Tole D, Walkinshaw MD, Griffin MD, Brouard S, Degauque N. Vabres B, et al. Among authors: walkinshaw md. Transplantation. 2024 Dec 12. doi: 10.1097/TP.0000000000005280. Online ahead of print. Transplantation. 2024. PMID: 39663555
Peripheral blood immune cell profiling of acute corneal transplant rejection.
Hjortdal J, Griffin MD, Cadoux M, Armitage WJ, Bylesjo M, Gabhann PM, Murphy CC, Pleyer U, Tole D, Vabres B, Walkinshaw MD, Gourraud PA, Karakachoff M, Brouard S, Degauque N. Hjortdal J, et al. Among authors: walkinshaw md. Am J Transplant. 2022 Oct;22(10):2337-2347. doi: 10.1111/ajt.17119. Epub 2022 Jun 29. Am J Transplant. 2022. PMID: 35704290 Free PMC article.
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
McNae IW, Kinkead J, Malik D, Yen LH, Walker MK, Swain C, Webster SP, Gray N, Fernandes PM, Myburgh E, Blackburn EA, Ritchie R, Austin C, Wear MA, Highton AJ, Keats AJ, Vong A, Dornan J, Mottram JC, Michels PAM, Pettit S, Walkinshaw MD. McNae IW, et al. Among authors: walkinshaw md. Nat Commun. 2021 Feb 16;12(1):1052. doi: 10.1038/s41467-021-21273-6. Nat Commun. 2021. PMID: 33594070 Free PMC article.
Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase.
Pinto Torres JE, Yuan M, Goossens J, Versées W, Caljon G, Michels PA, Walkinshaw MD, Magez S, Sterckx YG. Pinto Torres JE, et al. Among authors: walkinshaw md. Mol Biochem Parasitol. 2020 Mar;236:111263. doi: 10.1016/j.molbiopara.2020.111263. Epub 2020 Feb 19. Mol Biochem Parasitol. 2020. PMID: 32084384
Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis.
Fernandes PM, Kinkead J, McNae IW, Vásquez-Valdivieso M, Wear MA, Michels PAM, Walkinshaw MD. Fernandes PM, et al. Among authors: walkinshaw md. FEBS J. 2020 Jul;287(13):2847-2861. doi: 10.1111/febs.15177. Epub 2020 Jan 8. FEBS J. 2020. PMID: 31838765 Free PMC article.
194 results