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The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies.
Laskowski T, Kosno M, Andrałojć W, Frackowiak JE, Borzyszkowska-Bukowska J, Szczeblewski P, Radoń N, Świerżewska M, Woźny A, Paluszkiewicz E, Mazerska Z. Laskowski T, et al. Among authors: paluszkiewicz e. Sci Rep. 2023 Mar 1;13(1):3431. doi: 10.1038/s41598-023-30587-y. Sci Rep. 2023. PMID: 36859494 Free PMC article.
Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes.
Paluszkiewicz E, Horowska B, Borowa-Mazgaj B, Peszyńska-Sularz G, Paradziej-Łukowicz J, Augustin E, Konopa J, Mazerska Z. Paluszkiewicz E, et al. Eur J Med Chem. 2020 Oct 15;204:112599. doi: 10.1016/j.ejmech.2020.112599. Epub 2020 Jul 16. Eur J Med Chem. 2020. PMID: 32736230
In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme.
Potęga A, Rafalska D, Kazimierczyk D, Kosno M, Pawłowicz A, Andrałojć W, Paluszkiewicz E, Laskowski T. Potęga A, et al. Among authors: paluszkiewicz e. Molecules. 2023 Sep 26;28(19):6812. doi: 10.3390/molecules28196812. Molecules. 2023. PMID: 37836655 Free PMC article.
20 results