Jarman KE - Search Results

1

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc₁ Complex.

Nguyen W, Dans MG, Currie I, Awalt JK, Bailey BL, Lumb C, Ngo A, Favuzza P, Palandri J, Ramesh S, Penington J, Jarman KE, Mukherjee P, Chakraborty A, Maier AG, van Dooren GG, Papenfuss T, Wittlin S, Churchyard A, Baum J, Winzeler EA, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Nguyen W, et al. Among authors: jarman ke. ACS Infect Dis. 2023 Mar 10;9(3):668-691. doi: 10.1021/acsinfecdis.2c00607. Epub 2023 Feb 28. ACS Infect Dis. 2023. PMID: 36853190 Free PMC article.

2

CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.

Zhu W, Jarman KE, Lokman NA, Neubauer HA, Davies LT, Gliddon BL, Taing H, Moretti PAB, Oehler MK, Pitman MR, Pitson SM. Zhu W, et al. Among authors: jarman ke. Cancer Res. 2017 Sep 15;77(18):4823-4834. doi: 10.1158/0008-5472.CAN-17-0025. Epub 2017 Jul 20. Cancer Res. 2017. PMID: 28729416

3

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.

Jarman KE, Moretti PA, Zebol JR, Pitson SM. Jarman KE, et al. J Biol Chem. 2010 Jan 1;285(1):483-92. doi: 10.1074/jbc.M109.068395. Epub 2009 Oct 23. J Biol Chem. 2010. PMID: 19854831 Free PMC article.

4

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Schoenwaelder SM, Ono A, Nesbitt WS, Lim J, Jarman K, Jackson SP. Schoenwaelder SM, et al. J Biol Chem. 2010 Jan 22;285(4):2886-96. doi: 10.1074/jbc.M109.029132. Epub 2009 Nov 23. J Biol Chem. 2010. PMID: 19940148 Free PMC article.

5

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1.

Zhu W, Gliddon BL, Jarman KE, Moretti PAB, Tin T, Parise LV, Woodcock JM, Powell JA, Ruszkiewicz A, Pitman MR, Pitson SM. Zhu W, et al. Among authors: jarman ke. Oncogene. 2017 May 4;36(18):2619-2627. doi: 10.1038/onc.2016.428. Epub 2016 Dec 12. Oncogene. 2017. PMID: 27941888 Free PMC article.

6

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.

Schoenwaelder SM, Jarman KE, Gardiner EE, Hua M, Qiao J, White MJ, Josefsson EC, Alwis I, Ono A, Willcox A, Andrews RK, Mason KD, Salem HH, Huang DC, Kile BT, Roberts AW, Jackson SP. Schoenwaelder SM, et al. Among authors: jarman ke. Blood. 2011 Aug 11;118(6):1663-74. doi: 10.1182/blood-2011-04-347849. Epub 2011 Jun 14. Blood. 2011. PMID: 21673344 Free article.

7

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

Gazdik M, Jarman KE, O'Neill MT, Hodder AN, Lowes KN, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Gazdik M, et al. Among authors: jarman ke. Bioorg Med Chem. 2016 May 1;24(9):1993-2010. doi: 10.1016/j.bmc.2016.03.027. Epub 2016 Mar 16. Bioorg Med Chem. 2016. PMID: 27021426

8

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: jarman ke. J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26. J Med Chem. 2017. PMID: 28080063

9

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P₂ position of PEXEL peptidomimetics.

Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Nguyen W, et al. Among authors: jarman ke. Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub 2018 May 18. Eur J Med Chem. 2018. PMID: 29800827

10

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models.

Nguyen W, Jacobson J, Jarman KE, Jousset Sabroux H, Harty L, McMahon J, Lewin SR, Purcell DF, Sleebs BE. Nguyen W, et al. Among authors: jarman ke. J Med Chem. 2019 May 23;62(10):5148-5175. doi: 10.1021/acs.jmedchem.9b00462. Epub 2019 Apr 29. J Med Chem. 2019. PMID: 30973727

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