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Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.
Occean JR, Yang N, Sun Y, Dawkins MS, Munk R, Belair C, Dar S, Anerillas C, Wang L, Shi C, Dunn C, Bernier M, Price NL, Kim JS, Cui CY, Fan J, Bhattacharyya M, De S, Maragkakis M, deCabo R, Sidoli S, Sen P. Occean JR, et al. Among authors: sen p. bioRxiv [Preprint]. 2024 Jul 3:2023.02.15.528714. doi: 10.1101/2023.02.15.528714. bioRxiv. 2024. Update in: Nat Commun. 2024 Jul 28;15(1):6357. doi: 10.1038/s41467-024-50725-y PMID: 36824863 Free PMC article. Updated. Preprint.
The senescent cell epigenome.
Yang N, Sen P. Yang N, et al. Among authors: sen p. Aging (Albany NY). 2018 Nov 3;10(11):3590-3609. doi: 10.18632/aging.101617. Aging (Albany NY). 2018. PMID: 30391936 Free PMC article. Review.
circSamd4 represses myogenic transcriptional activity of PUR proteins.
Pandey PR, Yang JH, Tsitsipatis D, Panda AC, Noh JH, Kim KM, Munk R, Nicholson T, Hanniford D, Argibay D, Yang X, Martindale JL, Chang MW, Jones SW, Hernando E, Sen P, De S, Abdelmohsen K, Gorospe M. Pandey PR, et al. Among authors: sen p. Nucleic Acids Res. 2020 Apr 17;48(7):3789-3805. doi: 10.1093/nar/gkaa035. Nucleic Acids Res. 2020. PMID: 31980816 Free PMC article.
The eroding chromatin landscape of aging stem cells.
Shi C, Wang L, Sen P. Shi C, et al. Among authors: sen p. Transl Med Aging. 2020;4:121-131. doi: 10.1016/j.tma.2020.08.002. Epub 2020 Aug 17. Transl Med Aging. 2020. PMID: 33024907 Free PMC article.
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X, Mazan-Mamczarz K, Zhang Y, Heckenbach IJ, Scheibye-Knudsen M, De S, Sen P, Abdelmohsen K, Gorospe M. Herman AB, et al. Among authors: sen p. Nucleic Acids Res. 2021 Jul 21;49(13):7389-7405. doi: 10.1093/nar/gkab538. Nucleic Acids Res. 2021. PMID: 34181735 Free PMC article.
A gradual path to mortality.
Yang N, Sen P. Yang N, et al. Among authors: sen p. Elife. 2022 Mar 18;11:e77749. doi: 10.7554/eLife.77749. Elife. 2022. PMID: 35302485 Free PMC article.
Single-Cell Analysis of the Transcriptome and Epigenome.
Mazan-Mamczarz K, Ha J, De S, Sen P. Mazan-Mamczarz K, et al. Among authors: sen p. Methods Mol Biol. 2022;2399:21-60. doi: 10.1007/978-1-0716-1831-8_3. Methods Mol Biol. 2022. PMID: 35604552 Free PMC article.
1,555 results