Santos W - Search Results

1

Direct long read visualization reveals metabolic interplay between two antimalarial drug targets.

Liu S, Ebel ER, Luniewski A, Zulawinska J, Simpson ML, Kim J, Ene N, Braukmann TWA, Congdon M, Santos W, Yeh E, Guler JL. Liu S, et al. Among authors: santos w. bioRxiv [Preprint]. 2023 Dec 19:2023.02.13.528367. doi: 10.1101/2023.02.13.528367. bioRxiv. 2023. PMID: 36824743 Free PMC article. Preprint.

2

Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.

Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Congdon MD, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4956-4960. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. Bioorg Med Chem Lett. 2015. PMID: 25862200 Free PMC article.

3

Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels.

Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Kharel Y, et al. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31. doi: 10.1124/jpet.115.225862. Epub 2015 Aug 4. J Pharmacol Exp Ther. 2015. PMID: 26243740 Free PMC article.

4

Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.

Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL. Congdon MD, et al. ACS Med Chem Lett. 2016 Feb 2;7(3):229-34. doi: 10.1021/acsmedchemlett.5b00304. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985306 Free PMC article.

5

Extrachromosomal DNA amplicons in antimalarial-resistant Plasmodium falciparum.

McDaniels JM, Huckaby AC, Carter SA, Lingeman S, Francis A, Congdon M, Santos W, Rathod PK, Guler JL. McDaniels JM, et al. Among authors: santos w. Mol Microbiol. 2021 Apr;115(4):574-590. doi: 10.1111/mmi.14624. Epub 2020 Nov 19. Mol Microbiol. 2021. PMID: 33053232 Free PMC article.

6

Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.

Congdon M, Fritzemeier RG, Kharel Y, Brown AM, Serbulea V, Bevan DR, Lynch KR, Santos WL. Congdon M, et al. Eur J Med Chem. 2021 Feb 15;212:113121. doi: 10.1016/j.ejmech.2020.113121. Epub 2020 Dec 29. Eur J Med Chem. 2021. PMID: 33445156 Free PMC article.

7

Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to (Z)-1,3-Enynes.

Burgio AL, Buchbinder NW, Santos WL. Burgio AL, et al. Among authors: santos wl. Org Lett. 2023 Apr 21;25(15):2652-2656. doi: 10.1021/acs.orglett.3c00711. Epub 2023 Apr 6. Org Lett. 2023. PMID: 37023099

8

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target.

Kharel Y, Huang T, Dunnavant K, Foster D, Souza G, Nimchuk KE, Merchak AR, Pavelec CM, Juskiewicz ZJ, Gaultier A, Abbott S, Shin JB, Isakson BE, Xu W, Leitinger N, Santos WL, Lynch KR. Kharel Y, et al. Among authors: santos wl. bioRxiv [Preprint]. 2024 Apr 30:2024.03.26.586765. doi: 10.1101/2024.03.26.586765. bioRxiv. 2024. PMID: 38746194 Free PMC article. Preprint.

9

Phosphine-catalyzed hydroboration of propiolonitriles: access to (E)-1,2-vinylcyanotrifluoroborate derivatives.

Bowen J, Slebodnick C, Santos WL. Bowen J, et al. Chem Commun (Camb). 2022 May 17;58(40):5984-5987. doi: 10.1039/d2cc00603k. Chem Commun (Camb). 2022. PMID: 35481802

10

A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection.

Oyewole OO, Dunnavant K, Bhattarai S, Kharel Y, Lynch KR, Santos WL, Reid SP. Oyewole OO, et al. Viruses. 2022 May 24;14(6):1123. doi: 10.3390/v14061123. Viruses. 2022. PMID: 35746595 Free PMC article.

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