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The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Yu JH, Zhu BM, Wickre M, Riedlinger G, Chen W, Hosui A, Robinson GW, Hennighausen L. Yu JH, et al. Among authors: chen w. Hepatology. 2010 Nov;52(5):1808-18. doi: 10.1002/hep.23882. Hepatology. 2010. PMID: 21038417 Free PMC article.
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.
Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, Chan UI, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX. Xu X, et al. Among authors: chen m, chen q, chen e, chen w. Hum Mol Genet. 2019 Mar 1;28(5):842-857. doi: 10.1093/hmg/ddy398. Hum Mol Genet. 2019. PMID: 30445628 Free PMC article.
Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.
Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. Lee GS, et al. Among authors: chen w. J Biol Chem. 2013 May 24;288(21):15167-80. doi: 10.1074/jbc.M113.453936. Epub 2013 Apr 4. J Biol Chem. 2013. PMID: 23558686 Free PMC article.
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