Williams JT - Search Results

1

Molecular Mechanisms of MmpL3 Function and Inhibition.

Williams JT, Abramovitch RB. Williams JT, et al. Microb Drug Resist. 2023 May;29(5):190-212. doi: 10.1089/mdr.2021.0424. Epub 2023 Feb 21. Microb Drug Resist. 2023. PMID: 36809064 Free PMC article. Review.

2

HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.

Zheng H, Williams JT, Coulson GB, Haiderer ER, Abramovitch RB. Zheng H, et al. Among authors: williams jt. Antimicrob Agents Chemother. 2018 Jun 26;62(7):e02459-17. doi: 10.1128/AAC.02459-17. Print 2018 Jul. Antimicrob Agents Chemother. 2018. PMID: 29661875 Free PMC article.

3

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.

Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB. Williams JT, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00547-19. doi: 10.1128/AAC.00547-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405862 Free PMC article.

4

Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme.

Zheng H, Williams JT, Aleiwi B, Ellsworth E, Abramovitch RB. Zheng H, et al. Among authors: williams jt. ACS Chem Biol. 2020 Jan 17;15(1):52-62. doi: 10.1021/acschembio.8b00849. Epub 2019 Oct 14. ACS Chem Biol. 2020. PMID: 31556993 Free PMC article.

5

Artemisia annua and Artemisia afra extracts exhibit strong bactericidal activity against Mycobacterium tuberculosis.

Martini MC, Zhang T, Williams JT, Abramovitch RB, Weathers PJ, Shell SS. Martini MC, et al. Among authors: williams jt. J Ethnopharmacol. 2020 Nov 15;262:113191. doi: 10.1016/j.jep.2020.113191. Epub 2020 Jul 27. J Ethnopharmacol. 2020. PMID: 32730878 Free PMC article.

6

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus.

Belardinelli JM, Verma D, Li W, Avanzi C, Wiersma CJ, Williams JT, Johnson BK, Zimmerman M, Whittel N, Angala B, Wang H, Jones V, Dartois V, de Moura VCN, Gonzalez-Juarrero M, Pearce C, Schenkel AR, Malcolm KC, Nick JA, Charman SA, Wells TNC, Podell BK, Vennerstrom JL, Ordway DJ, Abramovitch RB, Jackson M. Belardinelli JM, et al. Among authors: williams jt. Sci Transl Med. 2022 Feb 23;14(633):eabj3860. doi: 10.1126/scitranslmed.abj3860. Epub 2022 Feb 23. Sci Transl Med. 2022. PMID: 35196022 Free PMC article.

7

Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and in vivo efficacy.

Eke IE, Williams JT, Haiderer ER, Albrecht VJ, Murdoch HM, Abdalla BJ, Abramovitch RB. Eke IE, et al. Among authors: williams jt. Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0047423. doi: 10.1128/aac.00474-23. Epub 2023 Aug 23. Antimicrob Agents Chemother. 2023. PMID: 37610224 Free PMC article.

8

A genetic selection for Mycobacterium smegmatis mutants tolerant to killing by sodium citrate defines a combined role for cation homeostasis and osmotic stress in cell death.

Williams JT, Baker JJ, Zheng H, Dechow SJ, Fallon J, Murto M, Albrecht VJ, Gilliland HN, Olive AJ, Abramovitch RB. Williams JT, et al. mSphere. 2023 Oct 24;8(5):e0035823. doi: 10.1128/msphere.00358-23. Epub 2023 Sep 8. mSphere. 2023. PMID: 37681985 Free PMC article.

9

The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection.

Williams JT, Giletto M, Haiderer ER, Aleiwi B, Krieger-Burke T, Ellsworth E, Abramovitch RB. Williams JT, et al. Microbiol Spectr. 2024 Jan 11;12(1):e0367723. doi: 10.1128/spectrum.03677-23. Epub 2023 Dec 11. Microbiol Spectr. 2024. PMID: 38078724 Free PMC article.

10

The Rip1 intramembrane protease contributes to iron and zinc homeostasis in Mycobacterium tuberculosis.

Nelson SJ, Williams JT, Buglino JA, Nambi S, Lojek LJ, Glickman MS, Ioerger TR, Sassetti CM. Nelson SJ, et al. Among authors: williams jt. mSphere. 2023 Aug 24;8(4):e0038922. doi: 10.1128/msphere.00389-22. Epub 2023 Jun 15. mSphere. 2023. PMID: 37318217 Free PMC article.

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