Fouqueray P - Search Results

1

Evaluation of PXL065 - deuterium-stabilized (R)-pioglitazone in patients with NASH: A phase II randomized placebo-controlled trial (DESTINY-1).

Harrison SA, Thang C, Bolze S, Dewitt S, Hallakou-Bozec S, Dubourg J, Bedossa P, Cusi K, Ratziu V, Grouin JM, Moller DE, Fouqueray P. Harrison SA, et al. Among authors: fouqueray p. J Hepatol. 2023 May;78(5):914-925. doi: 10.1016/j.jhep.2023.02.004. Epub 2023 Feb 18. J Hepatol. 2023. PMID: 36804402 Clinical Trial.

2

Imeglimin increases glucose-dependent insulin secretion and improves β-cell function in patients with type 2 diabetes.

Pacini G, Mari A, Fouqueray P, Bolze S, Roden M. Pacini G, et al. Among authors: fouqueray p. Diabetes Obes Metab. 2015 Jun;17(6):541-545. doi: 10.1111/dom.12452. Epub 2015 Mar 25. Diabetes Obes Metab. 2015. PMID: 25694060 Clinical Trial.

3

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG. Perry RJ, et al. Among authors: fouqueray p. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12. Am J Physiol Endocrinol Metab. 2016. PMID: 27406738 Free PMC article.

4

Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

Detaille D, Vial G, Borel AL, Cottet-Rouselle C, Hallakou-Bozec S, Bolze S, Fouqueray P, Fontaine E. Detaille D, et al. Among authors: fouqueray p. Cell Death Discov. 2016 Jan 18;2:15072. doi: 10.1038/cddiscovery.2015.72. eCollection 2016. Cell Death Discov. 2016. PMID: 27551496 Free PMC article.

5

Imeglimin Does Not Induce Clinically Relevant Pharmacokinetic Interactions When Combined with Either Metformin or Sitagliptin in Healthy Subjects.

Fouqueray P, Perrimond-Dauchy S, Bolze S. Fouqueray P, et al. Clin Pharmacokinet. 2020 Oct;59(10):1261-1271. doi: 10.1007/s40262-020-00886-y. Clin Pharmacokinet. 2020. PMID: 32270440 Clinical Trial.

6

Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.

Dubourg J, Perrimond-Dauchy S, Felices M, Bolze S, Voiriot P, Fouqueray P. Dubourg J, et al. Among authors: fouqueray p. Eur J Clin Pharmacol. 2020 Oct;76(10):1393-1400. doi: 10.1007/s00228-020-02929-6. Epub 2020 Jun 18. Eur J Clin Pharmacol. 2020. PMID: 32556539 Clinical Trial.

7

Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.

Chevalier C, Perrimond-Dauchy S, Dubourg J, Fouqueray P, Bolze S. Chevalier C, et al. Among authors: fouqueray p. Eur J Drug Metab Pharmacokinet. 2020 Dec;45(6):725-733. doi: 10.1007/s13318-020-00642-4. Eur J Drug Metab Pharmacokinet. 2020. PMID: 32860624 Clinical Trial.

8

Pharmacokinetics of Imeglimin in Subjects with Moderate Hepatic Impairment.

Chevalier C, Dubourg J, Bolze S, Fouqueray P. Chevalier C, et al. Among authors: fouqueray p. Clin Pharmacokinet. 2021 Apr;60(4):485-490. doi: 10.1007/s40262-020-00948-1. Epub 2020 Nov 9. Clin Pharmacokinet. 2021. PMID: 33169345 Clinical Trial.

9

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes.

Hallakou-Bozec S, Vial G, Kergoat M, Fouqueray P, Bolze S, Borel AL, Fontaine E, Moller DE. Hallakou-Bozec S, et al. Among authors: fouqueray p. Diabetes Obes Metab. 2021 Mar;23(3):664-673. doi: 10.1111/dom.14277. Epub 2020 Dec 29. Diabetes Obes Metab. 2021. PMID: 33269554 Free PMC article. Review.

10

Efficacy and safety of imeglimin in Japanese patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled, dose-ranging phase 2b trial.

Dubourg J, Ueki K, Grouin JM, Fouqueray P. Dubourg J, et al. Among authors: fouqueray p. Diabetes Obes Metab. 2021 Mar;23(3):800-810. doi: 10.1111/dom.14285. Epub 2021 Jan 13. Diabetes Obes Metab. 2021. PMID: 33275318 Free PMC article. Clinical Trial.

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