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Page 1
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. Ong HW, et al. Among authors: wichterle h. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527935. doi: 10.1101/2023.02.09.527935. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. doi: 10.1021/acschemneuro.3c00135. PMID: 36798313 Free PMC article. Updated. Preprint.
Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS).
Larrea D, Tamucci KA, Kabra K, Velasco KR, Yun TD, Pera M, Montesinos J, Agrawal RR, Paradas C, Smerdon JW, Lowry ER, Stepanova A, Yoval-Sanchez B, Galkin A, Wichterle H, Area-Gomez E. Larrea D, et al. Among authors: wichterle h. Nat Commun. 2025 Jan 3;16(1):379. doi: 10.1038/s41467-024-51578-1. Nat Commun. 2025. PMID: 39753538 Free PMC article.
Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.
Dorrity TJ, Shin H, Wiegand KA, Aruda J, Closser M, Jung E, Gertie JA, Leone A, Polfer R, Culbertson B, Yu L, Wu C, Ito T, Huang Y, Steckelberg AL, Wichterle H, Chung H. Dorrity TJ, et al. Among authors: wichterle h. Sci Immunol. 2023 Oct 27;8(88):eadg2979. doi: 10.1126/sciimmunol.adg2979. Epub 2023 Oct 20. Sci Immunol. 2023. PMID: 37862432 Free PMC article.
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.
Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L. Abarinov V, et al. Among authors: wichterle h. Genes Dev. 2023 Jun 1;37(11-12):490-504. doi: 10.1101/gad.350569.123. Epub 2023 Jun 26. Genes Dev. 2023. PMID: 37364986 Free PMC article.
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.
Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. Ong HW, et al. Among authors: wichterle h. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. doi: 10.1021/acschemneuro.3c00135. Epub 2023 Apr 21. ACS Chem Neurosci. 2023. PMID: 37084253 Free PMC article.
Ranking reprogramming factors for cell differentiation.
Hammelman J, Patel T, Closser M, Wichterle H, Gifford D. Hammelman J, et al. Among authors: wichterle h. Nat Methods. 2022 Jul;19(7):812-822. doi: 10.1038/s41592-022-01522-2. Epub 2022 Jun 16. Nat Methods. 2022. PMID: 35710610 Free PMC article.
78 results