Yan Y - Search Results

1

A novel CDK8 inhibitor with poly-substituted pyridine core: Discovery and anti-inflammatory activity evaluation in vivo.

Chen X, Yan Y, Cheng X, Zhang Z, He C, Wu D, Zhao D, Liu X. Chen X, et al. Among authors: yan y. Bioorg Chem. 2023 Apr;133:106402. doi: 10.1016/j.bioorg.2023.106402. Epub 2023 Feb 10. Bioorg Chem. 2023. PMID: 36791618

2

Discovery and SARs of 5-Chloro-N⁴-phenyl-N²-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors with Potent Antitumor Activity.

Wang Y, Chen X, Yan Y, Zhu X, Liu M, Liu X. Wang Y, et al. Among authors: yan y. J Med Chem. 2020 Mar 26;63(6):3327-3347. doi: 10.1021/acs.jmedchem.9b02121. Epub 2020 Mar 12. J Med Chem. 2020. PMID: 32129996

3

Angel or Devil ? - CDK8 as the new drug target.

Wu D, Zhang Z, Chen X, Yan Y, Liu X. Wu D, et al. Among authors: yan y. Eur J Med Chem. 2021 Mar 5;213:113043. doi: 10.1016/j.ejmech.2020.113043. Epub 2020 Nov 24. Eur J Med Chem. 2021. PMID: 33257171 Review.

4

Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor.

Chen X, Yan Y, Zhang Z, Zhang F, Liu M, Du L, Zhang H, Shen X, Zhao D, Shi JB, Liu X. Chen X, et al. Among authors: yan y. J Med Chem. 2021 Aug 26;64(16):11857-11885. doi: 10.1021/acs.jmedchem.1c00104. Epub 2021 Aug 10. J Med Chem. 2021. PMID: 34374541

5

Design and synthesis of the 4H-chromenone derivatives against psoriasis.

Zhang F, Yan Y, Han X, Du JC, Zhu R, Liu XH. Zhang F, et al. Among authors: yan y. Bioorg Chem. 2022 Mar;120:105640. doi: 10.1016/j.bioorg.2022.105640. Epub 2022 Jan 25. Bioorg Chem. 2022. PMID: 35121555

6

Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo.

Chen X, Yan Y, Du J, Shen X, He C, Pan H, Zhu J, Liu X. Chen X, et al. Among authors: yan y. Eur J Med Chem. 2022 Jun 5;236:114368. doi: 10.1016/j.ejmech.2022.114368. Epub 2022 Apr 10. Eur J Med Chem. 2022. PMID: 35429909

7

Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo.

Yan Y, Xing C, Xiao Y, Shen X, Zhang Z, He C, Shi JB, Liu M, Liu X. Yan Y, et al. J Med Chem. 2022 May 26;65(10):7334-7362. doi: 10.1021/acs.jmedchem.2c00356. Epub 2022 May 10. J Med Chem. 2022. PMID: 35536548

8

Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer.

Zhang XX, Xiao Y, Yan YY, Wang YM, Jiang H, Wu L, Shi JB, Liu XH. Zhang XX, et al. Among authors: yan yy. J Med Chem. 2022 Sep 22;65(18):12095-12123. doi: 10.1021/acs.jmedchem.2c00820. Epub 2022 Sep 6. J Med Chem. 2022. PMID: 36068975

9

Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy.

Yan YY, Zhang XX, Xiao Y, Shen XB, Jian YJ, Wang YM, She ZH, Liu MM, Liu XH. Yan YY, et al. J Med Chem. 2022 Oct 13;65(19):13216-13239. doi: 10.1021/acs.jmedchem.2c01042. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126227

10

Novel 2-phenyl-4H-chromen derivatives: synthesis and anti-inflammatory activity evaluation in vitro and in vivo.

Xiao Y, Yan Y, Du J, Feng X, Zhang F, Han X, Hu Y, Liu X. Xiao Y, et al. Among authors: yan y. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2589-2597. doi: 10.1080/14756366.2022.2124983. J Enzyme Inhib Med Chem. 2022. PMID: 36128868 Free PMC article.

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