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A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides.
Rosenberg YJ, Garcia K, Diener J, Sullivan D, Donahue S, Mao L, Lees J, Jiang X, Urban LA, Momper JD, Ho KY, Taylor P. Rosenberg YJ, et al. Among authors: mao l. J Neurochem. 2024 Apr;168(4):370-380. doi: 10.1111/jnc.15777. Epub 2023 Apr 6. J Neurochem. 2024. PMID: 36786545
Aerosolized recombinant human butyrylcholinesterase delivered by a nebulizer provides long term protection against inhaled paraoxon in macaques.
Rosenberg Y, Fink J, MacLoughlin R, Ooms-Konecny T, Sullivan D, Gerk W, Mao L, Jiang X, Lees J, Urban L, Rajendran N. Rosenberg Y, et al. Among authors: mao l. Chem Biol Interact. 2019 Aug 25;309:108712. doi: 10.1016/j.cbi.2019.06.025. Epub 2019 Jun 12. Chem Biol Interact. 2019. PMID: 31201777 Free PMC article.
4,844 results