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112 results

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Page 1
Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Harris LD, Regan MC, Myers SJ, Nocilla KA, Akins NS, Tahirovic YA, Wilson LJ, Dingledine R, Furukawa H, Traynelis SF, Liotta DC. Harris LD, et al. ACS Chem Neurosci. 2023 Mar 1;14(5):917-935. doi: 10.1021/acschemneuro.2c00779. Epub 2023 Feb 13. ACS Chem Neurosci. 2023. PMID: 36779874 Free PMC article.
Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor.
Epplin MP, Mohan A, Harris LD, Zhu Z, Strong KL, Bacsa J, Le P, Menaldino DS, Traynelis SF, Liotta DC. Epplin MP, et al. Among authors: harris ld. J Med Chem. 2020 Jul 23;63(14):7569-7600. doi: 10.1021/acs.jmedchem.9b01733. Epub 2020 Jul 6. J Med Chem. 2020. PMID: 32538088 Free PMC article.
Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor.
McSweeney AM, Eruera A-R, McKenzie-Goldsmith GM, Bouwer JC, Brown SHJ, Stubbing LA, Hubert JG, Shrestha R, Sparrow KJ, Brimble MA, Harris LD, Evans GB, Bostina M, Krause KL, Ward VK. McSweeney AM, et al. Among authors: harris ld. J Virol. 2024 Nov 19;98(11):e0119324. doi: 10.1128/jvi.01193-24. Epub 2024 Oct 30. J Virol. 2024. PMID: 39475276 Free PMC article.
An efficient regioconvergent synthesis of 3-aza-obeticholic acid.
Harris LD, Aponte RAL, Jiao W, Cameron SA, Weymouth-Wilson A, Furneaux RH, Compton BJ, Luxenburger A. Harris LD, et al. Steroids. 2024 Dec;212:109517. doi: 10.1016/j.steroids.2024.109517. Epub 2024 Sep 24. Steroids. 2024. PMID: 39322098 Free article.
Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients.
Sala S, Nitschke P, Masuda R, Gray N, Lawler NG, Wood JM, Buckler JN, Berezhnoy G, Bolaños J, Boughton BA, Lonati C, Rössler T, Singh Y, Wilson ID, Lodge S, Morillon AC, Loo RL, Hall D, Whiley L, Evans GB, Grove TL, Almo SC, Harris LD, Holmes E, Merle U, Trautwein C, Nicholson JK, Wist J. Sala S, et al. Among authors: harris ld. J Proteome Res. 2024 Mar 1;23(3):956-970. doi: 10.1021/acs.jproteome.3c00654. Epub 2024 Feb 4. J Proteome Res. 2024. PMID: 38310443 Free PMC article.
Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.
Heier JS, Lad EM, Holz FG, Rosenfeld PJ, Guymer RH, Boyer D, Grossi F, Baumal CR, Korobelnik JF, Slakter JS, Waheed NK, Metlapally R, Pearce I, Steinle N, Francone AA, Hu A, Lally DR, Deschatelets P, Francois C, Bliss C, Staurenghi G, Monés J, Singh RP, Ribeiro R, Wykoff CC; OAKS and DERBY study investigators. Heier JS, et al. Lancet. 2023 Oct 21;402(10411):1434-1448. doi: 10.1016/S0140-6736(23)01520-9. Lancet. 2023. PMID: 37865470 Clinical Trial.
112 results