Hussack G - Search Results

1

Structure-guided design of a potent Clostridiodes difficile toxin A inhibitor.

Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Hussack G, et al. Front Microbiol. 2023 Jan 26;14:1110541. doi: 10.3389/fmicb.2023.1110541. eCollection 2023. Front Microbiol. 2023. PMID: 36778856 Free PMC article.

2

Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain.

Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J. Hussack G, et al. J Biol Chem. 2011 Mar 18;286(11):8961-76. doi: 10.1074/jbc.M110.198754. Epub 2011 Jan 7. J Biol Chem. 2011. PMID: 21216961 Free PMC article.

3

Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives.

Hussack G, Tanha J. Hussack G, et al. Toxins (Basel). 2010 May;2(5):998-1018. doi: 10.3390/toxins2050998. Epub 2010 May 7. Toxins (Basel). 2010. PMID: 22069622 Free PMC article. Review.

4

Engineered single-domain antibodies with high protease resistance and thermal stability.

Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J. Hussack G, et al. PLoS One. 2011;6(11):e28218. doi: 10.1371/journal.pone.0028218. Epub 2011 Nov 30. PLoS One. 2011. PMID: 22140551 Free PMC article.

5

Multivalent anchoring and oriented display of single-domain antibodies on cellulose.

Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R. Hussack G, et al. Sensors (Basel). 2009;9(7):5351-67. doi: 10.3390/s90705351. Epub 2009 Jul 7. Sensors (Basel). 2009. PMID: 22346702 Free PMC article.

6

A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders.

Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J. Hussack G, et al. Protein Eng Des Sel. 2012 Jun;25(6):313-8. doi: 10.1093/protein/gzs014. Epub 2012 Apr 6. Protein Eng Des Sel. 2012. PMID: 22490957

7

Modulation of toxin production by the flagellar regulon in Clostridium difficile.

Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM. Aubry A, et al. Among authors: hussack g. Infect Immun. 2012 Oct;80(10):3521-32. doi: 10.1128/IAI.00224-12. Epub 2012 Jul 30. Infect Immun. 2012. PMID: 22851750 Free PMC article.

8

Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies.

Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J. Hussack G, et al. Methods Mol Biol. 2012;911:211-39. doi: 10.1007/978-1-61779-968-6_14. Methods Mol Biol. 2012. PMID: 22886255

9

Characterization of single-domain antibodies with an engineered disulfide bond.

Hussack G, Mackenzie CR, Tanha J. Hussack G, et al. Methods Mol Biol. 2012;911:417-29. doi: 10.1007/978-1-61779-968-6_25. Methods Mol Biol. 2012. PMID: 22886266

10

Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile.

Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. Murase T, et al. Among authors: hussack g. J Biol Chem. 2014 Jan 24;289(4):2331-43. doi: 10.1074/jbc.M113.505917. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24311789 Free PMC article.

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