Zhu C - Search Results

1

2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.

Chen P, Tang G, Zhu C, Sun J, Wang X, Xiang M, Huang H, Wang W, Li L, Zhang ZM, Gao L, Yao SQ. Chen P, et al. Among authors: zhu c. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print. J Am Chem Soc. 2023. PMID: 36774655

2

Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery".

Fan Y, Si H, Zhang Z, Zhong L, Sun H, Zhu C, Yin Z, Li H, Tang G, Yao SQ, Sun P, Zhang ZM, Ding K, Li Z. Fan Y, et al. Among authors: zhu c. J Med Chem. 2021 Nov 11;64(21):15582-15592. doi: 10.1021/acs.jmedchem.0c02024. Epub 2021 Oct 8. J Med Chem. 2021. PMID: 34623802

3

Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase.

Chen P, Sun J, Zhu C, Tang G, Wang W, Xu M, Xiang M, Zhang CJ, Zhang ZM, Gao L, Yao SQ. Chen P, et al. Among authors: zhu c. Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202203878. doi: 10.1002/anie.202203878. Epub 2022 Apr 29. Angew Chem Int Ed Engl. 2022. PMID: 35438229

4

Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor.

Ouyang Y, Si H, Zhu C, Zhong L, Ma H, Li Z, Xiong H, Liu T, Liu Z, Zhang Z, Zhang ZM, Cai Q. Ouyang Y, et al. Among authors: zhu c. J Med Chem. 2022 Jun 9;65(11):7833-7842. doi: 10.1021/acs.jmedchem.2c00271. Epub 2022 May 18. J Med Chem. 2022. PMID: 35584513

5

Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons.

Sun J, Lin XM, Lu DH, Wang M, Li K, Li SR, Li ZQ, Zhu CJ, Zhang ZM, Yan CY, Pan MH, Gong HB, Feng JC, Cao YF, Huang F, Sun WY, Kurihara H, Li YF, Duan WJ, Jiao GL, Zhang L, He RR. Sun J, et al. J Clin Invest. 2023 May 15;133(10):e165228. doi: 10.1172/JCI165228. J Clin Invest. 2023. PMID: 37183824 Free PMC article.

6

Ynamide Coupling Reagent for the Chemical Cross-Linking of Proteins in Live Cells.

Li S, Zhu C, Zhao Q, Zhang ZM, Sun P, Li Z. Li S, et al. Among authors: zhu c. ACS Chem Biol. 2023 Jun 16;18(6):1405-1415. doi: 10.1021/acschembio.3c00149. Epub 2023 May 25. ACS Chem Biol. 2023. PMID: 37231651

7

Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently.

Wang W, Wang X, Tang G, Zhu C, Xiang M, Xiao Q, Zhang ZM, Gao L, Yao SQ. Wang W, et al. Among authors: zhu c. Chem Commun (Camb). 2023 Sep 7;59(72):10789-10792. doi: 10.1039/d3cc03530a. Chem Commun (Camb). 2023. PMID: 37594149

8

Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.

Tang G, Wang W, Zhu C, Huang H, Chen P, Wang X, Xu M, Sun J, Zhang CJ, Xiao Q, Gao L, Zhang ZM, Yao SQ. Tang G, et al. Among authors: zhu c. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202316394. doi: 10.1002/anie.202316394. Epub 2024 Feb 14. Angew Chem Int Ed Engl. 2024. PMID: 38248139

9

Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.

Tang Z, Li J, Peng L, Xu F, Tan Y, He X, Zhu C, Zhang ZM, Zhang Z, Sun P, Ding K, Li Z. Tang Z, et al. Among authors: zhu c. J Med Chem. 2024 Feb 8;67(3):1872-1887. doi: 10.1021/acs.jmedchem.3c01608. Epub 2024 Jan 24. J Med Chem. 2024. PMID: 38265413

10

Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies.

Sun J, Lou L, Zhu C, Chen P, Tang G, Gu M, Xia S, Dong X, Zhang ZM, Gao L, Yao SQ, Xiao Q. Sun J, et al. Among authors: zhu c. J Adv Res. 2024 Sep 8:S2090-1232(24)00392-8. doi: 10.1016/j.jare.2024.09.008. Online ahead of print. J Adv Res. 2024. PMID: 39255927 Free article.

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