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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.
Vinyard ME, Su C, Siegenfeld AP, Waterbury AL, Freedy AM, Gosavi PM, Park Y, Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB. Vinyard ME, et al. Among authors: gosavi pm. Nat Chem Biol. 2019 May;15(5):529-539. doi: 10.1038/s41589-019-0263-0. Epub 2019 Apr 15. Nat Chem Biol. 2019. PMID: 30992567 Free PMC article.
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
Xie X, Zhang O, Yeo MJR, Lee C, Harry SA, Paul L, Li Y, Payne NC, Nam E, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB. Xie X, et al. Among authors: gosavi pm. bioRxiv [Preprint]. 2024 May 14:2024.05.14.593970. doi: 10.1101/2024.05.14.593970. bioRxiv. 2024. PMID: 38798357 Free PMC article. Preprint.
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
Yeo MJ, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N. Yeo MJ, et al. Among authors: gosavi pm. bioRxiv [Preprint]. 2024 May 14:2024.05.14.593897. doi: 10.1101/2024.05.14.593897. bioRxiv. 2024. PMID: 38798619 Free PMC article. Preprint.
13 results