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Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors.
Ficarro SB, Marto ZH, Girardi NM, Deng D, Maisonet IJ, Adelmant G, Fleming LE, Sharafi M, Tavares I, Zhao A, Kim H, Seo HS, Dhe-Paganon S, Buhrlage SJ, Marto JA. Ficarro SB, et al. Among authors: girardi nm. SLAS Discov. 2024 Dec;29(8):100198. doi: 10.1016/j.slasd.2024.100198. Epub 2024 Nov 30. SLAS Discov. 2024. PMID: 39622293 Free article.
Accelerating inhibitor discovery for deubiquitinating enzymes.
Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, Varca AC, Hu B, Bratt AS, DaSilva E, Schauer NJ, Jaen Maisonet I, Dolen EK, Ayala AX, Marto JA, Buhrlage SJ. Chan WC, et al. Among authors: girardi nm. Nat Commun. 2023 Feb 8;14(1):686. doi: 10.1038/s41467-023-36246-0. Nat Commun. 2023. PMID: 36754960 Free PMC article.
A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood.
Turco AE, Oakes SR, Keil Stietz KP, Dunham CL, Joseph DB, Chathurvedula TS, Girardi NM, Schneider AJ, Gawdzik J, Sheftel CM, Wang P, Wang Z, Bjorling DE, Ricke WA, Tang W, Hernandez LL, Keast JR, Bonev AD, Grimes MD, Strand DW, Tykocki NR, Tanguay RL, Peterson RE, Vezina CM. Turco AE, et al. Among authors: girardi nm. Dis Model Mech. 2021 Jul 1;14(7):dmm049068. doi: 10.1242/dmm.049068. Epub 2021 Jul 27. Dis Model Mech. 2021. PMID: 34318329 Free PMC article.
Genetic background but not prostatic epithelial beta-catenin influences susceptibility of male mice to testosterone and estradiol-induced urinary dysfunction.
Wegner KA, Ruetten H, Girardi NM, O'Driscoll CA, Sandhu JK, Turco AE, Abler LL, Wang P, Wang Z, Bjorling DE, Malinowski R, Peterson RE, Strand DW, Marker PC, Vezina CM. Wegner KA, et al. Among authors: girardi nm. Am J Clin Exp Urol. 2021 Feb 15;9(1):121-131. eCollection 2021. Am J Clin Exp Urol. 2021. PMID: 33816700 Free PMC article.
An immunohistochemical prostate cell identification key indicates that aging shifts procollagen 1A1 production from myofibroblasts to fibroblasts in dogs prone to prostate-related urinary dysfunction.
Ruetten H, Cole C, Wehber M, Wegner KA, Girardi NM, Peterson NT, Scharpf BR, Romero MF, Wood MW, Colopy SA, Bjorling DE, Vezina CM. Ruetten H, et al. Among authors: girardi nm. PLoS One. 2020 Jul 29;15(7):e0232564. doi: 10.1371/journal.pone.0232564. eCollection 2020. PLoS One. 2020. PMID: 32726309 Free PMC article.