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Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog.
Ping X, Meyer MJ, Zahn NM, Golani LK, Sharmin D, Pandey KP, Revanian S, Mondal P, Jin X, Arnold LA, Cerne R, Cook JM, Divović B, Savić MM, Lippa A, Smith JL, Witkin JM. Ping X, et al. Among authors: cook jm. Drug Dev Res. 2023 May;84(3):527-531. doi: 10.1002/ddr.22042. Epub 2023 Feb 7. Drug Dev Res. 2023. PMID: 36748904
Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation.
Pandey KP, Divović B, Rashid F, Golani LK, Cerne R, Zahn NM, Meyer MJ, Arnold LA, Sharmin D, Mian MY, Smith JL, Ping X, Jin X, Lippa A, Tiruveedhula VVNPB, Cook JM, Savić MM, Witkin JM. Pandey KP, et al. Among authors: cook jm. J Pharmacol Exp Ther. 2023 Apr;385(1):50-61. doi: 10.1124/jpet.122.001362. Epub 2023 Feb 6. J Pharmacol Exp Ther. 2023. PMID: 36746611 Free PMC article.
Development and validation of an LC-MS/MS method for the determination of ARN14988, an acid ceramidase inhibitor, and its application to a pharmacokinetic study in a mouse model.
Rajaratnam V, Islam MM, Kub EF, Rajaratnam S, Kim KB, Rahman MT, Rashid F, Benko AM, Cook JM, Arnold LA, Mirza SP. Rajaratnam V, et al. Among authors: cook jm. Biomed Chromatogr. 2024 Jan;38(1):e5754. doi: 10.1002/bmc.5754. Epub 2023 Sep 26. Biomed Chromatogr. 2024. PMID: 37750452
Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome.
Nakakubo S, Hiramatsu Y, Goto T, Kimura S, Narugami M, Nakajima M, Ueda Y, Shiraishi H, Manabe A, Sharmin D, Cook JM, Egawa K. Nakakubo S, et al. Among authors: cook jm. Front Pharmacol. 2023 Oct 2;14:1273633. doi: 10.3389/fphar.2023.1273633. eCollection 2023. Front Pharmacol. 2023. PMID: 37849734 Free PMC article.
Development of non-sedating benzodiazepines with in vivo antischistosomal activity.
Mian MY, Sharmin D, Mondal P, Belayet JB, Hossain MM, McCusker P, Ryan KT, Fedorov AY, Green HA, Ericksen SS, Zamanian M, Tiruveedhula VVNPB, Cook JM, Chan JD. Mian MY, et al. Among authors: cook jm. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0036924. doi: 10.1128/aac.00369-24. Epub 2024 Aug 13. Antimicrob Agents Chemother. 2024. PMID: 39136467
628 results