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Gene-SGAN: a method for discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering.
Yang Z, Wen J, Abdulkadir A, Cui Y, Erus G, Mamourian E, Melhem R, Srinivasan D, Govindarajan ST, Chen J, Habes M, Masters CL, Maruff P, Fripp J, Ferrucci L, Albert MS, Johnson SC, Morris JC, LaMontagne P, Marcus DS, Benzinger TLS, Wolk DA, Shen L, Bao J, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Yang Z, et al. Among authors: johnson sc. ArXiv [Preprint]. 2023 Jan 25:arXiv:2301.10772v1. ArXiv. 2023. Update in: Nat Commun. 2024 Jan 8;15(1):354. doi: 10.1038/s41467-023-44271-2 PMID: 36748000 Free PMC article. Updated. Preprint.
Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measures.
Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga A, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Bryan NR, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Yang Z, et al. Among authors: johnson sc. medRxiv [Preprint]. 2023 Dec 30:2023.12.29.23300642. doi: 10.1101/2023.12.29.23300642. medRxiv. 2023. PMID: 38234857 Free PMC article. Preprint.
Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.
Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters KD, Shashikumar N, Pechman KR, Kim ME, Gao C, Mohd Khairi N, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford KA, Wilson JE, Cambronero FE, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Toga AW, Thompson PM, Mormino EC, Habes M, Wang D, Zhang P, Schilling K; Alzheimer's Disease Neuroimaging Initiative (ADNI); BIOCARD Study Team; Alzheimer's Disease Sequencing Project (ADSP); Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB. Peterson A, et al. Among authors: johnson sc. Alzheimers Dement. 2024 Dec 22. doi: 10.1002/alz.14343. Online ahead of print. Alzheimers Dement. 2024. PMID: 39711105
Targeted Proteomic Biomarker Profiling Using NULISA in a cohort enriched with risk for Alzheimer's Disease and Related Dementias.
Reyes RER, Wilson RE, Langhough RE, Studer RL, Jonaitis EM, Oomens JE, Planalp EM, Bendlin BB, Chin NA, Asthana S, Zetterberg H, Johnson SC. Reyes RER, et al. Among authors: johnson sc. medRxiv [Preprint]. 2024 Nov 29:2024.11.28.24318162. doi: 10.1101/2024.11.28.24318162. medRxiv. 2024. PMID: 39649596 Free PMC article. Preprint.
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).
Mormino EC, Biber SA, Rahman-Filipiak A, Arfanakis K, Clark L, Dage JL, Detre JA, Dickerson BC, Donohue MC, Kecskemeti S, Hohman TJ, Jagust WJ, Keene DC, Kukull W, Levendovszky SR, Rosen H, Thompson PM, Villemagne VL, Wolk DA, Okonkwo OC, Rabinvovici GD, Rivera-Mindt M, Foroud T, Johnson SC. Mormino EC, et al. Among authors: johnson sc. Alzheimers Dement. 2024 Nov 26. doi: 10.1002/alz.14383. Online ahead of print. Alzheimers Dement. 2024. PMID: 39588767 Review.
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease.
Rea Reyes RE, Cody KA, Wilson RE, Zetterberg H, Chin NA, Jonaitis EM, Bahr M, Mandel O, Wintlend M, Bendlin BB, Okonkwo OC, Clark LR, Zammit M, Asthana S, Christian BT, Betthauser TJ, Eisenmenger L, Langhough RE, Johnson SC. Rea Reyes RE, et al. Among authors: johnson sc. Alzheimers Dement. 2024 Nov 19. doi: 10.1002/alz.14406. Online ahead of print. Alzheimers Dement. 2024. PMID: 39560002
Amyloid-β positivity is less prevalent in cognitively unimpaired KLOTHO KL-VS heterozygotes.
Cook N, Driscoll I, Gaitán JM, Glittenberg M, Betthauser TJ, Carlsson CM, Johnson SC, Asthana S, Zetterberg H, Blennow K, Kollmorgen G, Quijano-Rubio C, Dubal DB, Okonkwo OC. Cook N, et al. Among authors: johnson sc. J Alzheimers Dis. 2024 Nov;102(2):480-490. doi: 10.1177/13872877241289785. Epub 2024 Nov 11. J Alzheimers Dis. 2024. PMID: 39529379
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.
Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). Xicota L, et al. EBioMedicine. 2024 Dec;110:105433. doi: 10.1016/j.ebiom.2024.105433. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500037 Free PMC article.
937 results