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Page 1
Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy.
Walker FM, Sobral LM, Danis E, Sanford B, Balakrishnan I, Wang D, Pierce A, Karam SD, Serkova NJ, Foreman NK, Venkataraman S, Dowell R, Vibhakar R, Dahl NA. Walker FM, et al. Among authors: karam sd. bioRxiv [Preprint]. 2023 Jan 25:2023.01.24.525424. doi: 10.1101/2023.01.24.525424. bioRxiv. 2023. Update in: Nat Commun. 2024 May 30;15(1):4616. doi: 10.1038/s41467-024-48214-3 PMID: 36747867 Free PMC article. Updated. Preprint.
Short-term Topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis.
Contreras-Zárate MJ, Alvarez-Eraso KL, Jaramillo-Gómez JA, Littrell Z, Tsuji N, Ormond DR, Karam SD, Kabos P, Cittelly DM. Contreras-Zárate MJ, et al. Among authors: karam sd. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528559. doi: 10.1101/2023.02.14.528559. bioRxiv. 2023. Update in: Neuro Oncol. 2023 Oct 3;25(10):1802-1814. doi: 10.1093/neuonc/noad070 PMID: 36824740 Free PMC article. Updated. Preprint.
IL15/IL15Rα complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1+ CD8 T cells.
Piper M, Gadwa J, Hodgson C, Knitz M, Yee E, Zhu Y, Larson KY, Klein C, Amann M, Saviola A, Karam SD. Piper M, et al. Among authors: karam sd. bioRxiv [Preprint]. 2024 Sep 22:2024.09.18.613691. doi: 10.1101/2024.09.18.613691. bioRxiv. 2024. PMID: 39345626 Free PMC article. Preprint.
Cancer immunotherapy response persists after lymph node resection.
Zhou H, Menzel L, Baish JW, O'Melia MJ, Darragh LB, Specht E, Effiom DN, Czapla J, Lei PJ, Rajotte JJ, Liu L, Nikmaneshi MR, Razavi MS, Vander Heiden MG, Ubellacker JM, Munn LL, Karam SD, Boland GM, Cohen S, Padera TP. Zhou H, et al. Among authors: karam sd. bioRxiv [Preprint]. 2024 Dec 11:2023.09.19.558262. doi: 10.1101/2023.09.19.558262. bioRxiv. 2024. PMID: 37781599 Free PMC article. Preprint.
The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression.
Corbo S, Nguyen D, Bhatia S, Darragh LB, Abdelazeem KNM, Court BV, Olimpo NA, Gadwa J, Yu J, Hodgson C, Samedi V, Garcia ES, Siu L, Saviola A, Heasley LE, Knitz MW, Pasquale EB, Karam SD. Corbo S, et al. Among authors: karam sd. bioRxiv [Preprint]. 2024 Aug 13:2024.08.13.607778. doi: 10.1101/2024.08.13.607778. bioRxiv. 2024. PMID: 39211197 Free PMC article. Preprint.
Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment.
Gadwa J, Yu J, Piper M, Knitz MW, Darragh LB, Olimpo N, Corbo S, Beynor JI, Neupert B, Nguyen AT, Hodgson C, Nguyen D, Abdelazeem KN, Saviola A, Pousse L, Bransi A, Pincha M, Klein C, Amann M, Karam SD. Gadwa J, et al. Among authors: karam sd. J Immunother Cancer. 2025 Jan 7;13(1):e010405. doi: 10.1136/jitc-2024-010405. J Immunother Cancer. 2025. PMID: 39773568 Free article.
Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference.
Laurent PA, André F, Bobard A, Deandreis D, Demaria S, Depil S, Eichmüller SB, Fernandez-Palomo C, Foijer F, Galluzzi L, Galon J, Guckenberger M, Harrington KJ, Herrera FG, Huber PE, Italiano A, Karam SD, Kroemer G, Lambin P, Leuschner C, Mantovani A, Meylan E, Mondini M, Pittet MJ, Pouget JP, Remon J, Sørensen CS, Sotiriou C, Vanpouille-Box C, Weichselbaum RR, Welsh JW, Zitvogel L, Formenti SC, Deutsch E. Laurent PA, et al. Among authors: karam sd. Oncoimmunology. 2025 Dec;14(1):2432726. doi: 10.1080/2162402X.2024.2432726. Epub 2024 Dec 18. Oncoimmunology. 2025. PMID: 39696783 Free PMC article.
MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-β in squamous cell carcinomas with enhanced CD8 T cell memory-driven response.
Lind HT, Hall SC, Strait AA, Goon JB, Aleman JD, Chen SMY, Karam SD, Young CD, Wang JH, Wang XJ. Lind HT, et al. Among authors: karam sd. Cancer Lett. 2025 Jan 1;608:217347. doi: 10.1016/j.canlet.2024.217347. Epub 2024 Nov 22. Cancer Lett. 2025. PMID: 39580046
Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC.
Abdelazeem KNM, Nguyen D, Corbo S, Darragh LB, Matsumoto MW, Van Court B, Neupert B, Yu J, Olimpo NA, Osborne DG, Gadwa J, Ross RB, Nguyen A, Bhatia S, Kapoor M, Friedman RS, Jacobelli J, Saviola AJ, Knitz MW, Pasquale EB, Karam SD. Abdelazeem KNM, et al. Among authors: karam sd. Oncogene. 2025 Feb;44(3):130-146. doi: 10.1038/s41388-024-03208-9. Epub 2024 Nov 3. Oncogene. 2025. PMID: 39489818 Free article.
157 results