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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
Taylor MS, Connie W, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cheng WC, Heaps J, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Norden BL, Chait BT, Goggins M, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Jung E, Arora KS, Zukerberg LR, Yilmaz OH, Chi G, Matulonis UA, Song Y, Nieman L, Parikh AR, Strickland M, Corcoran RB, Mustelin T, Eng G, Yilmaz ÃH, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH. Taylor MS, et al. Among authors: lacava j. bioRxiv [Preprint]. 2023 Mar 17:2023.01.25.525462. doi: 10.1101/2023.01.25.525462. bioRxiv. 2023. Update in: Cancer Discov. 2023 Dec 12;13(12):2532-2547. doi: 10.1158/2159-8290.CD-23-0313 PMID: 36747644 Free PMC article. Updated. Preprint.
RNA-quality control by the exosome.
Houseley J, LaCava J, Tollervey D. Houseley J, et al. Among authors: lacava j. Nat Rev Mol Cell Biol. 2006 Jul;7(7):529-39. doi: 10.1038/nrm1964. Nat Rev Mol Cell Biol. 2006. PMID: 16829983 Review.
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome.
Huiting W, Dekker SL, van der Lienden JCJ, Mergener R, Musskopf MK, Furtado GV, Gerrits E, Coit D, Oghbaie M, Di Stefano LH, Schepers H, van Waarde-Verhagen MAWH, Couzijn S, Barazzuol L, LaCava J, Kampinga HH, Bergink S. Huiting W, et al. Among authors: lacava j. Elife. 2022 Feb 24;11:e70726. doi: 10.7554/eLife.70726. Elife. 2022. PMID: 35200138 Free PMC article.
Correction to: The Eukaryotic RNA Exosome.
LaCava J, Vaňáčová Š. LaCava J, et al. Methods Mol Biol. 2020;2062:C1-C4. doi: 10.1007/978-1-4939-9822-7_25. Methods Mol Biol. 2020. PMID: 33252726
91 results