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Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
Aguirre S, Luthra P, Sanchez-Aparicio MT, Maestre AM, Patel J, Lamothe F, Fredericks AC, Tripathi S, Zhu T, Pintado-Silva J, Webb LG, Bernal-Rubio D, Solovyov A, Greenbaum B, Simon V, Basler CF, Mulder LC, García-Sastre A, Fernandez-Sesma A. Aguirre S, et al. Among authors: pintado silva j. Nat Microbiol. 2017 Mar 27;2:17037. doi: 10.1038/nmicrobiol.2017.37. Nat Microbiol. 2017. PMID: 28346446 Free PMC article.
Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS.
Webb LG, Veloz J, Pintado-Silva J, Zhu T, Rangel MV, Mutetwa T, Zhang L, Bernal-Rubio D, Figueroa D, Carrau L, Fenutria R, Potla U, Reid SP, Yount JS, Stapleford KA, Aguirre S, Fernandez-Sesma A. Webb LG, et al. Among authors: pintado silva j. PLoS Pathog. 2020 Oct 15;16(10):e1008999. doi: 10.1371/journal.ppat.1008999. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33057424 Free PMC article.