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Page 1
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
Dong S, Zhao Z, Tang H, Li G, Pan J, Gu X, Jiang J, Xiao L, Scapin G, Hunter DN, Yang D, Huang Y, Bennett F, Yang SW, Mandal M, Tang H, Su J, Tudge C, deJesus RK, Ding FX, Lombardo M, Hicks JD, Fischmann T, Mirza A, Dayananth P, Painter RE, Villafania A, Garlisi CG, Zhang R, Mayhood TW, Si Q, Li N, Amin RP, Bhatt B, Chen F, Regan CP, Regan H, Lin X, Wu J, Leithead A, Pollack SR, Scott JD, Nargund RP, Therien AG, Black T, Young K, Pasternak A. Dong S, et al. Among authors: leithead a. J Med Chem. 2024 Mar 14;67(5):3400-3418. doi: 10.1021/acs.jmedchem.3c01614. Epub 2024 Feb 22. J Med Chem. 2024. PMID: 38387069
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Wang H, Ishchenko A, Skudlarek J, Shen P, Dzhekieva L, Painter RE, Chen YT, Bukhtiyarova M, Leithead A, Tracy R, Babaoglu K, Bahnck-Teets C, Buevich A, Cabalu TD, Labroli M, Lange H, Lei Y, Li W, Liu J, Mann PA, Meng T, Mitchell HJ, Mulhearn J, Scapin G, Sha D, Shaw AW, Si Q, Tong L, Wu C, Wu Z, Xiao JC, Xu M, Zhang LK, McKenney D, Miller RR, Black TA, Cooke A, Balibar CJ, Klein DJ, Raheem I, Walker SS. Wang H, et al. Among authors: leithead a. Nat Microbiol. 2024 May;9(5):1244-1255. doi: 10.1038/s41564-024-01667-0. Epub 2024 Apr 22. Nat Microbiol. 2024. PMID: 38649414
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues.
Bennett F, Huang Y, Dong S, Jiang J, Hunter D, Zhao Z, Gu X, Scott JD, Tang H, Yang D, Xiao L, Scapin G, Fischmann T, Mirza A, Dayananth P, Painter RE, Villafania A, Garlisi CG, Zhang R, Mayhood TW, Si Q, Li N, Amin RP, Chen F, Bhatt B, Regan CP, Regan H, Lin X, Wu J, Leithead A, Young K, Pasternak A. Bennett F, et al. Among authors: leithead a. Bioorg Med Chem Lett. 2024 Dec 1;114:129989. doi: 10.1016/j.bmcl.2024.129989. Epub 2024 Oct 11. Bioorg Med Chem Lett. 2024. PMID: 39396683
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
Plotkin MA, Labroli M, Schubert J, Shaw A, Schlegel KS, Berger R, Cooke AJ, Hayes RP, Armacost KA, Kinek K, Krosky P, Burlein C, Meng S, DiNunzio E, Murray EM, Agrawal S, Madeira M, Flattery A, Yao H, Leithead A, Rose WA 2nd, Cox C, Tellers DM, McKenna PM, Raheem I. Plotkin MA, et al. Among authors: leithead a. ACS Med Chem Lett. 2024 Jul 9;15(8):1232-1241. doi: 10.1021/acsmedchemlett.4c00117. eCollection 2024 Aug 8. ACS Med Chem Lett. 2024. PMID: 39140041
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
Skudlarek JW, Cooke AJ, Mitchell HJ, Babaoglu K, Shaw AW, Tong L, Nomland AB, Labroli M, Sha D, Mulhearn JJ, Wu C, Li SW, Beshore DC, Hughes JME, Jouffroy M, Wang H, Balibar CJ, Painter RE, Shen P, Lange HS, Ishchenko A, Chen YT, Klein DJ, Tracy RW, Miller RR, Cabalu TD, Wu Z, Leithead A, Scapin G, Hruza AW, Dzhekieva L, Bukhtiyarova M, Homsher MF, Xu M, Bahnck-Teets C, McKenney D, Buevich AV, Liu J, Zhang LK, Meng T, Kelly T, DiNunzio E, Soisson S, Cheng RKY, Hennig M, Raheem I, Walker SS. Skudlarek JW, et al. Among authors: leithead a. J Med Chem. 2024 Sep 12;67(17):15620-15675. doi: 10.1021/acs.jmedchem.4c01277. Epub 2024 Aug 22. J Med Chem. 2024. PMID: 39172133
Organic carbon dry deposition outpaces atmospheric processing with unaccounted implications for air quality and freshwater ecosystems.
Liggio J, Makar P, Li SM, Hayden K, Darlington A, Moussa S, Wren S, Staebler R, Wentzell J, Wheeler M, Leithead A, Mittermeier R, Narayan J, Wolde M, Blanchard D, Aherne J, Kirk J, Lee C, Stroud C, Zhang J, Akingunola A, Katal A, Cheung P, Ghahreman R, Majdzadeh M, He M, Ditto J, Gentner DR. Liggio J, et al. Among authors: leithead a. Sci Adv. 2025 Jan 3;11(1):eadr0259. doi: 10.1126/sciadv.adr0259. Epub 2025 Jan 3. Sci Adv. 2025. PMID: 39752507 Free PMC article.
26 results