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The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation.
Lai JP, Oseini AM, Moser CD, Yu C, Elsawa SF, Hu C, Nakamura I, Han T, Aderca I, Isomoto H, Garrity-Park MM, Shire AM, Li J, Sanderson SO, Adjei AA, Fernandez-Zapico ME, Roberts LR. Lai JP, et al. Among authors: roberts lr. Hepatology. 2010 Nov;52(5):1680-9. doi: 10.1002/hep.23848. Hepatology. 2010. PMID: 20725905 Free PMC article.
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.
Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK, Guerrero RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Shire AM, Nagorney DM, Sanderson SO, Adjei AA, Lee JS, Thorgeirsson SS, Roberts LR. Lai JP, et al. Among authors: roberts lr. Hepatology. 2008 Apr;47(4):1211-22. doi: 10.1002/hep.22202. Hepatology. 2008. PMID: 18318435 Free PMC article.
The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
Aderca I, Moser CD, Veerasamy M, Bani-Hani AH, Bonilla-Guerrero R, Ahmed K, Shire A, Cazanave SC, Montoya DP, Mettler TA, Burgart LJ, Nagorney DM, Thibodeau SN, Cunningham JM, Lai JP, Roberts LR. Aderca I, et al. Among authors: roberts lr. J Hepatol. 2008 Sep;49(3):373-83. doi: 10.1016/j.jhep.2008.05.015. Epub 2008 Jun 9. J Hepatol. 2008. PMID: 18620777 Free PMC article.
538 results