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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy.
Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. Perez-Garcia G, et al. Among authors: de gasperi r. Neurosci Lett. 2023 Feb 16;797:137080. doi: 10.1016/j.neulet.2023.137080. Epub 2023 Jan 16. Neurosci Lett. 2023. PMID: 36657633 Free PMC article.
Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures.
Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, Kawoos U, Hogg S, Ache B, Sowa A, Tetreault T, Varghese M, Cook DG, Zhu CW, Tappan SJ, Janssen WGM, Hof PR, Ahlers ST, Elder GA. Gama Sosa MA, et al. Among authors: de gasperi r. Acta Neuropathol Commun. 2023 May 12;11(1):81. doi: 10.1186/s40478-023-01553-6. Acta Neuropathol Commun. 2023. PMID: 37173747 Free PMC article.
Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure.
De Gasperi R, Gama Sosa MA, Perez Garcia G, Perez GM, Pryor D, Morrison CL, Lind R, Abutarboush R, Kawoos U, Statz JK, Patterson J, Hof PR, Zhu CW, Ahlers ST, Cook DG, Elder GA. De Gasperi R, et al. J Neurotrauma. 2024 Mar;41(5-6):714-733. doi: 10.1089/neu.2023.0252. Epub 2023 Dec 19. J Neurotrauma. 2024. PMID: 37917117
Exposure to Low-Intensity Blast Increases Clearance of Brain Amyloid Beta.
Abutarboush R, Reed E, Chen Y, Gu M, Watson C, Kawoos U, Statz JK, Tschiffely AE, Ciarlone S, Perez-Garcia G, Gama Sosa MA, de Gasperi R, Stone JR, Elder GA, Ahlers ST. Abutarboush R, et al. Among authors: de gasperi r. J Neurotrauma. 2024 Mar;41(5-6):685-704. doi: 10.1089/neu.2023.0284. Epub 2024 Jan 23. J Neurotrauma. 2024. PMID: 38183627
The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma.
Elder GA, Gama Sosa MA, De Gasperi R, Perez Garcia G, Perez GM, Abutarboush R, Kawoos U, Zhu CW, Janssen WGM, Stone JR, Hof PR, Cook DG, Ahlers ST. Elder GA, et al. Among authors: de gasperi r. Int J Mol Sci. 2024 Jan 17;25(2):1150. doi: 10.3390/ijms25021150. Int J Mol Sci. 2024. PMID: 38256223 Free PMC article. Review.
Beneficial effects of physical exercise and an orally active mGluR2/3 antagonist pro-drug on neurogenesis and behavior in an Alzheimer's amyloidosis model.
Perez Garcia G, Bicak M, Buros J, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Gage FH, Barlow C, Dudley JT, Glicksberg BS, Wang Y, Readhead B, Ehrlich ME, Elder GA, Gandy S. Perez Garcia G, et al. Among authors: de gasperi r. Front Dement. 2023 Sep 6;2:1198006. doi: 10.3389/frdem.2023.1198006. eCollection 2023. Front Dement. 2023. PMID: 39081972 Free PMC article.
117 results