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Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Neuwirt E, et al. Among authors: reinheckel t. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. Sci Signal. 2023. PMID: 36649377
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T. Tholen M, et al. Among authors: reinheckel t. J Biol Chem. 2015 Jun 19;290(25):15758-15769. doi: 10.1074/jbc.M114.624353. Epub 2015 May 8. J Biol Chem. 2015. PMID: 25957406 Free PMC article.
Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes.
Thriene K, Grüning BA, Bornert O, Erxleben A, Leppert J, Athanasiou I, Weber E, Kiritsi D, Nyström A, Reinheckel T, Backofen R, Has C, Bruckner-Tuderman L, Dengjel J. Thriene K, et al. Among authors: reinheckel t. Mol Cell Proteomics. 2018 Apr;17(4):565-579. doi: 10.1074/mcp.RA117.000437. Epub 2018 Jan 11. Mol Cell Proteomics. 2018. PMID: 29326176 Free PMC article.
The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.
Pensa S, Neoh K, Resemann HK, Kreuzaler PA, Abell K, Clarke NJ, Reinheckel T, Kahn CR, Watson CJ. Pensa S, et al. Among authors: reinheckel t. Cell Death Differ. 2014 Sep;21(9):1442-50. doi: 10.1038/cdd.2014.59. Epub 2014 Jun 6. Cell Death Differ. 2014. PMID: 24902901 Free PMC article.
185 results