Bowman C - Search Results

1

Evaluation of bottom-up modeling of the blood-brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling.

Bowman C, Ma F, Mao J, Plise E, Chen E, Liu L, Zhang S, Chen Y. Bowman C, et al. Biopharm Drug Dispos. 2023 Feb;44(1):60-70. doi: 10.1002/bdd.2344. Epub 2023 Feb 7. Biopharm Drug Dispos. 2023. PMID: 36630933

2

Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma.

Bowman CM, Chen E, Chen L, Chen YC, Liang X, Wright M, Chen Y, Mao J. Bowman CM, et al. Drug Metab Dispos. 2020 Jan;48(1):18-24. doi: 10.1124/dmd.119.088948. Epub 2019 Nov 7. Drug Metab Dispos. 2020. PMID: 31699807

3

Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin.

Bowman CM, Ma F, Mao J, Chen Y. Bowman CM, et al. CPT Pharmacometrics Syst Pharmacol. 2021 Jan;10(1):5-17. doi: 10.1002/psp4.12571. Epub 2020 Dec 15. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33220025 Free PMC article. Review.

4

Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.

Bowman CM, Chen B, Cheong J, Liu L, Chen Y, Mao J. Bowman CM, et al. Drug Metab Dispos. 2021 Jul;49(7):530-539. doi: 10.1124/dmd.120.000315. Epub 2021 May 6. Drug Metab Dispos. 2021. PMID: 33958385

5

Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds.

Mao J, Ma F, Yu J, Bruyn T, Ning M, Bowman C, Chen Y. Mao J, et al. Among authors: bowman c. Biopharm Drug Dispos. 2023 Aug;44(4):315-334. doi: 10.1002/bdd.2359. Epub 2023 May 9. Biopharm Drug Dispos. 2023. PMID: 37160730

6

Understanding CYP3A4 and P-gp mediated drug-drug interactions through PBPK modeling - Case example of pralsetinib.

Bowman C, Dolton M, Ma F, Cheeti S, Kuruvilla D, Sane R, Kassir N, Chen Y. Bowman C, et al. CPT Pharmacometrics Syst Pharmacol. 2024 Apr;13(4):660-672. doi: 10.1002/psp4.13114. Epub 2024 Mar 13. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38481038 Free PMC article.

7

Integrating Dynamic in vitro Systems and Mechanistic Absorption Modeling: Case Study of Pralsetinib.

Dolton MJ, Bowman C, Ma F, Cheeti S, Kuruvilla D, Kassir N, Chen Y, Liu J, Chiang PC. Dolton MJ, et al. Among authors: bowman c. J Pharm Sci. 2024 Sep;113(9):2952-2956. doi: 10.1016/j.xphs.2024.07.006. Epub 2024 Jul 26. J Pharm Sci. 2024. PMID: 39002726

8

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.

Bowman CM, Benet LZ. Bowman CM, et al. Drug Metab Dispos. 2016 Nov;44(11):1731-1735. doi: 10.1124/dmd.116.071514. Epub 2016 Aug 12. Drug Metab Dispos. 2016. PMID: 27519549 Free PMC article.

9

The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.

Bowman CM, Okochi H, Benet LZ. Bowman CM, et al. Drug Metab Dispos. 2019 Apr;47(4):358-363. doi: 10.1124/dmd.118.085779. Epub 2019 Jan 23. Drug Metab Dispos. 2019. PMID: 30674616 Free PMC article.

10

In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly.

Bowman CM, Benet LZ. Bowman CM, et al. Drug Metab Dispos. 2019 Dec;47(12):1368-1371. doi: 10.1124/dmd.119.088427. Epub 2019 Sep 24. Drug Metab Dispos. 2019. PMID: 31551322 Free PMC article.

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