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Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV Jr, Kukar T, Tansey MG. Chen X, et al. Among authors: chang j. J Neurosci. 2013 May 22;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013. J Neurosci. 2013. PMID: 23699531 Free PMC article.
Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration.
Kannarkat GT, Lee JK, Ramsey CP, Chung J, Chang J, Porter I, Oliver D, Shepherd K, Tansey MG. Kannarkat GT, et al. Among authors: chang j. Neurobiol Aging. 2015 May;36(5):1982-93. doi: 10.1016/j.neurobiolaging.2015.02.006. Epub 2015 Feb 13. Neurobiol Aging. 2015. PMID: 25784210 Free PMC article.
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study.
Kannarkat GT, Cook DA, Lee JK, Chang J, Chung J, Sandy E, Paul KC, Ritz B, Bronstein J, Factor SA, Boss JM, Tansey MG. Kannarkat GT, et al. Among authors: chang j. NPJ Parkinsons Dis. 2015;1:15002-. doi: 10.1038/npjparkd.2015.2. Epub 2015 Apr 22. NPJ Parkinsons Dis. 2015. PMID: 27148593 Free PMC article.
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.
de Sousa Rodrigues ME, Bekhbat M, Houser MC, Chang J, Walker DI, Jones DP, Oller do Nascimento CMP, Barnum CJ, Tansey MG. de Sousa Rodrigues ME, et al. Among authors: chang j. Brain Behav Immun. 2017 Jan;59:158-172. doi: 10.1016/j.bbi.2016.08.021. Epub 2016 Sep 2. Brain Behav Immun. 2017. PMID: 27592562 Free PMC article.
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
MacPherson KP, Sompol P, Kannarkat GT, Chang J, Sniffen L, Wildner ME, Norris CM, Tansey MG. MacPherson KP, et al. Among authors: chang j. Neurobiol Dis. 2017 Jun;102:81-95. doi: 10.1016/j.nbd.2017.02.010. Epub 2017 Feb 24. Neurobiol Dis. 2017. PMID: 28237313 Free PMC article.
LRRK2 levels in immune cells are increased in Parkinson's disease.
Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, Grigoryan N, Factor SA, West AB, Boss JM, Tansey MG. Cook DA, et al. Among authors: chang j. NPJ Parkinsons Dis. 2017 Mar 28;3:11. doi: 10.1038/s41531-017-0010-8. eCollection 2017. NPJ Parkinsons Dis. 2017. PMID: 28649611 Free PMC article.
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