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The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.
Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G. Han L, et al. Among authors: ostrowski mc. Nat Commun. 2023 Jan 3;14(1):1. doi: 10.1038/s41467-022-34464-6. Nat Commun. 2023. PMID: 36596776 Free PMC article.
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC. Lefler JE, et al. Among authors: ostrowski mc. Life Sci Alliance. 2022 Jul 8;5(11):e202201460. doi: 10.26508/lsa.202201460. Print 2022 Nov. Life Sci Alliance. 2022. PMID: 35803738 Free PMC article.
Pten in stromal fibroblasts suppresses mammary epithelial tumours.
Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G. Trimboli AJ, et al. Among authors: ostrowski mc. Nature. 2009 Oct 22;461(7267):1084-91. doi: 10.1038/nature08486. Nature. 2009. PMID: 19847259 Free PMC article.
Stromal PTEN determines mammary epithelial response to radiotherapy.
Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC. Sizemore GM, et al. Among authors: ostrowski mc. Nat Commun. 2018 Jul 17;9(1):2783. doi: 10.1038/s41467-018-05266-6. Nat Commun. 2018. PMID: 30018330 Free PMC article.
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
Khan I, Marelia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, Pécot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP. Khan I, et al. Among authors: ostrowski mc. Small GTPases. 2022 Jan;13(1):114-127. doi: 10.1080/21541248.2021.1906621. Epub 2021 May 5. Small GTPases. 2022. PMID: 33949915 Free PMC article.
PTEN in cancer associated fibroblasts.
Lefler JE, Seward C, Ostrowski MC. Lefler JE, et al. Among authors: ostrowski mc. Adv Cancer Res. 2022;154:203-226. doi: 10.1016/bs.acr.2022.01.002. Epub 2022 Mar 18. Adv Cancer Res. 2022. PMID: 35459470
PTEN in the Stroma.
Thies KA, Lefler JE, Leone G, Ostrowski MC. Thies KA, et al. Among authors: ostrowski mc. Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a036111. doi: 10.1101/cshperspect.a036111. Cold Spring Harb Perspect Med. 2019. PMID: 31427286 Free PMC article. Review.
175 results