Liu X - Search Results

1

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.

Sun C, Cheng Y, Liu X, Wang G, Min W, Wang X, Yuan K, Hou Y, Li J, Zhang H, Dong H, Wang L, Lou C, Sun Y, Yu X, Deng H, Xiao Y, Yang P. Sun C, et al. Among authors: liu x. Acta Pharm Sin B. 2022 Dec;12(12):4446-4457. doi: 10.1016/j.apsb.2022.04.007. Epub 2022 Apr 16. Acta Pharm Sin B. 2022. PMID: 36561991 Free PMC article.

2

Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells.

Liu L, Zhang N, Dou Y, Mao G, Bi C, Pang W, Liu X, Song D, Deng H. Liu L, et al. Among authors: liu x. Sci Rep. 2017 Jan 31;7:41862. doi: 10.1038/srep41862. Sci Rep. 2017. PMID: 28139733 Free PMC article.

3

Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP_L in hepatocellular carcinoma.

Zhang N, Liu X, Liu L, Deng Z, Zeng Q, Pang W, Liu Y, Song D, Deng H. Zhang N, et al. Among authors: liu y, liu x, liu l. Cell Death Dis. 2018 Feb 14;9(2):230. doi: 10.1038/s41419-018-0309-3. Cell Death Dis. 2018. PMID: 29445085 Free PMC article.

4

Discovery and Development of 8-Substituted Cycloberberine Derivatives as Novel Antibacterial Agents against MRSA.

Fan T, Hu X, Tang S, Liu X, Wang Y, Deng H, You X, Jiang J, Li Y, Song D. Fan T, et al. Among authors: liu x. ACS Med Chem Lett. 2018 Apr 16;9(5):484-489. doi: 10.1021/acsmedchemlett.8b00094. eCollection 2018 May 10. ACS Med Chem Lett. 2018. PMID: 29795764 Free PMC article.

5

MPB, a novel berberine derivative, enhances lysosomal and bactericidal properties via TGF-β-activated kinase 1-dependent activation of the transcription factor EB.

Liu X, Zhang N, Liu Y, Liu L, Zeng Q, Yin M, Wang Y, Song D, Deng H. Liu X, et al. Among authors: liu y, liu l. FASEB J. 2019 Jan;33(1):1468-1481. doi: 10.1096/fj.201801198R. Epub 2018 Aug 30. FASEB J. 2019. PMID: 30161000

Therefore, our study reveals a novel mechanism by which MPB controls JNK and AMPK phosphorylation cascades to activate lysosomal function and bactericidal activity via TAK1 K158-dependent manner, which may offer insight into novel therapeutic strategies to control bacterial infec …

Therefore, our study reveals a novel mechanism by which MPB controls JNK and AMPK phosphorylation cascades to activate lysosomal function an …

6

Resibufogenin suppresses transforming growth factor-β-activated kinase 1-mediated nuclear factor-κB activity through protein kinase C-dependent inhibition of glycogen synthase kinase 3.

Liu L, Liu Y, Liu X, Zhang N, Mao G, Zeng Q, Yin M, Song D, Deng H. Liu L, et al. Among authors: liu y, liu x. Cancer Sci. 2018 Nov;109(11):3611-3622. doi: 10.1111/cas.13788. Epub 2018 Sep 23. Cancer Sci. 2018. PMID: 30168902 Free PMC article.

7

SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1.

Zhang N, Dou Y, Liu L, Zhang X, Liu X, Zeng Q, Liu Y, Yin M, Liu X, Deng H, Song D. Zhang N, et al. Among authors: liu y, liu x, liu l. EBioMedicine. 2019 Feb;40:151-162. doi: 10.1016/j.ebiom.2019.01.054. Epub 2019 Jan 31. EBioMedicine. 2019. PMID: 30711516 Free PMC article.

8

Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.

Liu Y, Liu X, Zhang N, Yin M, Dong J, Zeng Q, Mao G, Song D, Liu L, Deng H. Liu Y, et al. Among authors: liu x, liu l. Acta Pharm Sin B. 2020 Dec;10(12):2299-2312. doi: 10.1016/j.apsb.2020.06.014. Epub 2020 Jun 30. Acta Pharm Sin B. 2020. PMID: 33354502 Free PMC article.

9

Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity.

Zeng Q, Deng H, Li Y, Fan T, Liu Y, Tang S, Wei W, Liu X, Guo X, Jiang J, Wang Y, Song D. Zeng Q, et al. Among authors: liu y, liu x. J Med Chem. 2021 Jan 14;64(1):768-781. doi: 10.1021/acs.jmedchem.0c01743. Epub 2020 Dec 1. J Med Chem. 2021. PMID: 33440945

10

Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR.

Liu X, Yin M, Dong J, Mao G, Min W, Kuang Z, Yang P, Liu L, Zhang N, Deng H. Liu X, et al. Among authors: liu l. Acta Pharm Sin B. 2021 Oct;11(10):3134-3149. doi: 10.1016/j.apsb.2021.03.039. Epub 2021 Apr 1. Acta Pharm Sin B. 2021. PMID: 34745852 Free PMC article.

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