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Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel®85 Protects K18-hACE2 Mice against Lethal Virus Challenge.
Nechooshtan R, Ehrlich S, Vitikainen M, Makovitzki A, Dor E, Marcus H, Hefetz I, Pitel S, Wiebe M, Huuskonen A, Cherry L, Lupu E, Sapir Y, Holtzman T, Aftalion M, Gur D, Tamir H, Yahalom-Ronen Y, Ramot Y, Kronfeld N, Zarling D, Vallerga A, Tchelet R, Nyska A, Saloheimo M, Emalfarb M, Ophir Y. Nechooshtan R, et al. Among authors: emalfarb m. Vaccines (Basel). 2022 Dec 11;10(12):2119. doi: 10.3390/vaccines10122119. Vaccines (Basel). 2022. PMID: 36560529 Free PMC article.
In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum.
Espinosa LA, Ramos Y, Andújar I, Torres EO, Cabrera G, Martín A, Roche D, Chinea G, Becquet M, González I, Canaán-Haden C, Nelson E, Rojas G, Pérez-Massón B, Pérez-Martínez D, Boggiano T, Palacio J, Lozada Chang SL, Hernández L, de la Luz Hernández KR, Markku S, Vitikainen M, Valdés-Balbín Y, Santana-Medero D, Rivera DG, Vérez-Bencomo V, Emalfarb M, Tchelet R, Guillén G, Limonta M, Pimentel E, Ayala M, Besada V, González LJ. Espinosa LA, et al. Among authors: emalfarb m. Anal Bioanal Chem. 2021 Dec;413(30):7559-7585. doi: 10.1007/s00216-021-03721-w. Epub 2021 Nov 5. Anal Bioanal Chem. 2021. PMID: 34739558 Free PMC article.
A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice.
Lazo L, Bequet-Romero M, Lemos G, Musacchio A, Cabrales A, Bruno AJ, Ariel Espinosa L, Saloheimo M, Vitikainen M, Hernández A, Emalfarb M, Tchelet R, Suzarte E, Guillén G. Lazo L, et al. Among authors: emalfarb m. Vaccine. 2022 Feb 16;40(8):1162-1169. doi: 10.1016/j.vaccine.2022.01.007. Epub 2022 Jan 19. Vaccine. 2022. PMID: 35078661 Free PMC article.
Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform.
Ramot Y, Kronfeld N, Ophir Y, Ezov N, Friedman S, Saloheimo M, Vitikainen M, Ben-Artzi H, Avigdor A, Tchelet R, Valbuena Crespo N, Emalfarb M, Nyska A. Ramot Y, et al. Among authors: emalfarb m. Toxicol Pathol. 2022 Apr;50(3):294-307. doi: 10.1177/01926233221090518. Epub 2022 May 5. Toxicol Pathol. 2022. PMID: 35514116 Free PMC article.
Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1.
Gonzalez-Hernandez M, Kaiser FK, Steffen I, Ciurkiewicz M, van Amerongen G, Tchelet R, Emalfarb M, Saloheimo M, Wiebe MG, Vitikainen M, Albulescu IC, Bosch BJ, Baumgärtner W, Haagmans BL, Osterhaus ADME. Gonzalez-Hernandez M, et al. Among authors: emalfarb m. Front Immunol. 2023 Jun 9;14:1204834. doi: 10.3389/fimmu.2023.1204834. eCollection 2023. Front Immunol. 2023. PMID: 37359531 Free PMC article.
Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models.
Kaiser FK, Hernandez MG, Krüger N, Englund E, Du W, Mykytyn AZ, Raadsen MP, Lamers MM, Rodrigues Ianiski F, Shamorkina TM, Snijder J, Armando F, Beythien G, Ciurkiewicz M, Schreiner T, Gruber-Dujardin E, Bleyer M, Batura O, Erffmeier L, Hinkel R, Rocha C, Mirolo M, Drabek D, Bosch BJ, Emalfarb M, Valbuena N, Tchelet R, Baumgärtner W, Saloheimo M, Pöhlmann S, Grosveld F, Haagmans BL, Osterhaus ADME. Kaiser FK, et al. Among authors: emalfarb m. Nat Commun. 2024 Mar 14;15(1):2319. doi: 10.1038/s41467-024-46443-0. Nat Commun. 2024. PMID: 38485931 Free PMC article.