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The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.
Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. Mergy MA, et al. Among authors: blakely rd. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4779-88. doi: 10.1073/pnas.1417294111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331903 Free PMC article.
Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.
Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD. Simmler LD, et al. Among authors: blakely rd. Br J Pharmacol. 2017 Aug;174(16):2716-2738. doi: 10.1111/bph.13899. Epub 2017 Jul 11. Br J Pharmacol. 2017. PMID: 28585320 Free PMC article.
Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559.
Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD. Gowrishankar R, et al. Among authors: blakely rd. J Neurosci. 2018 Jun 6;38(23):5302-5312. doi: 10.1523/JNEUROSCI.0055-18.2018. Epub 2018 May 8. J Neurosci. 2018. PMID: 29739866 Free PMC article.
343 results