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canSAR 2024-an update to the public drug discovery knowledgebase.
Gingrich PW, Chitsazi R, Biswas A, Jiang C, Zhao L, Tym JE, Brammer KM, Li J, Shu Z, Maxwell DS, Tacy JA, Mica IL, Darkoh M, di Micco P, Russell KP, Workman P, Al-Lazikani B. Gingrich PW, et al. Among authors: workman p. Nucleic Acids Res. 2024 Nov 13:gkae1050. doi: 10.1093/nar/gkae1050. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39535036
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
Pasqua AE, Sharp SY, Chessum NEA, Hayes A, Pellegrino L, Tucker MJ, Miah A, Wilding B, Evans LE, Rye CS, Mok NY, Liu M, Henley AT, Gowan S, De Billy E, Te Poele R, Powers M, Eccles SA, Clarke PA, Raynaud FI, Workman P, Jones K, Cheeseman MD. Pasqua AE, et al. Among authors: workman p. J Med Chem. 2023 Apr 27;66(8):5907-5936. doi: 10.1021/acs.jmedchem.3c00156. Epub 2023 Apr 5. J Med Chem. 2023. PMID: 37017629 Free PMC article.
canSAR: update to the cancer translational research and drug discovery knowledgebase.
di Micco P, Antolin AA, Mitsopoulos C, Villasclaras-Fernandez E, Sanfelice D, Dolciami D, Ramagiri P, Mica IL, Tym JE, Gingrich PW, Hu H, Workman P, Al-Lazikani B. di Micco P, et al. Among authors: workman p. Nucleic Acids Res. 2023 Jan 6;51(D1):D1212-D1219. doi: 10.1093/nar/gkac1004. Nucleic Acids Res. 2023. PMID: 36624665 Free PMC article.
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes.
Samant RS, Batista S, Larance M, Ozer B, Milton CI, Bludau I, Wu E, Biggins L, Andrews S, Hervieu A, Johnston HE, Al-Lazikhani B, Lamond AI, Clarke PA, Workman P. Samant RS, et al. Among authors: workman p. Mol Cell Proteomics. 2023 Feb;22(2):100485. doi: 10.1016/j.mcpro.2022.100485. Epub 2022 Dec 20. Mol Cell Proteomics. 2023. PMID: 36549590 Free PMC article.
The era of high-quality chemical probes.
Licciardello MP, Workman P. Licciardello MP, et al. Among authors: workman p. RSC Med Chem. 2022 Nov 28;13(12):1446-1459. doi: 10.1039/d2md00291d. eCollection 2022 Dec 14. RSC Med Chem. 2022. PMID: 36545432 Free PMC article.
605 results