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Page 1
Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease.
Zhu Y, Dwidar M, Nemet I, Buffa JA, Sangwan N, Li XS, Anderson JT, Romano KA, Fu X, Funabashi M, Wang Z, Keranahalli P, Battle S, Tittle AN, Hajjar AM, Gogonea V, Fischbach MA, DiDonato JA, Hazen SL. Zhu Y, et al. Among authors: didonato ja. Cell Host Microbe. 2023 Jan 11;31(1):18-32.e9. doi: 10.1016/j.chom.2022.11.015. Epub 2022 Dec 21. Cell Host Microbe. 2023. PMID: 36549300 Free PMC article.
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure.
Romano KA, Nemet I, Prasad Saha P, Haghikia A, Li XS, Mohan ML, Lovano B, Castel L, Witkowski M, Buffa JA, Sun Y, Li L, Menge CM, Demuth I, König M, Steinhagen-Thiessen E, DiDonato JA, Deb A, Bäckhed F, Tang WHW, Naga Prasad SV, Landmesser U, Van Wagoner DR, Hazen SL. Romano KA, et al. Among authors: didonato ja. Circ Heart Fail. 2023 Jan;16(1):e009972. doi: 10.1161/CIRCHEARTFAILURE.122.009972. Epub 2022 Dec 16. Circ Heart Fail. 2023. PMID: 36524472 Free PMC article. Clinical Trial.
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.
Ferrell M, Wang Z, Anderson JT, Li XS, Witkowski M, DiDonato JA, Hilser JR, Hartiala JA, Haghikia A, Cajka T, Fiehn O, Sangwan N, Demuth I, König M, Steinhagen-Thiessen E, Landmesser U, Tang WHW, Allayee H, Hazen SL. Ferrell M, et al. Among authors: didonato ja. Nat Med. 2024 Feb;30(2):424-434. doi: 10.1038/s41591-023-02793-8. Epub 2024 Feb 19. Nat Med. 2024. PMID: 38374343
Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.
Ferrell M, Wang Z, Anderson JT, Li XS, Witkowski M, DiDonato JA, Hilser JR, Hartiala JA, Haghikia A, Cajka T, Fiehn O, Sangwan N, Demuth I, König M, Steinhagen-Thiessen E, Landmesser U, Tang WHW, Allayee H, Hazen SL. Ferrell M, et al. Among authors: didonato ja. Nat Med. 2024 Jun;30(6):1791. doi: 10.1038/s41591-024-02899-7. Nat Med. 2024. PMID: 38448791 No abstract available.
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.
Tang WHW, DiDonato JA, Allayee H, Hazen SL. Tang WHW, et al. Among authors: didonato ja. Nat Med. 2024 Sep;30(9):2448-2449. doi: 10.1038/s41591-024-03222-0. Epub 2024 Sep 5. Nat Med. 2024. PMID: 39237627 No abstract available.
Trimethylamine N-Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations.
Tang WHW, Lemaitre RN, Jensen PN, Wang M, Wang Z, Li XS, Nemet I, Lee Y, Lai HTM, de Oliveira Otto MC, Fretts AM, Sotoodehnia N, DiDonato JA, Bäckhed F, Psaty BM, Siscovick DS, Budoff MJ, Mozaffarian D, Hazen SL. Tang WHW, et al. Among authors: didonato ja. Circ Heart Fail. 2024 Aug;17(8):e011569. doi: 10.1161/CIRCHEARTFAILURE.124.011569. Epub 2024 Aug 9. Circ Heart Fail. 2024. PMID: 39119698
Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors.
Saha PP, Gogonea V, Sweet W, Mohan ML, Singh KD, Anderson JT, Mallela D, Witherow C, Kar N, Stenson K, Harford T, Fischbach MA, Brown JM, Karnik SS, Moravec CS, DiDonato JA, Naga Prasad SV, Hazen SL. Saha PP, et al. Among authors: didonato ja. Nat Commun. 2024 Aug 6;15(1):6696. doi: 10.1038/s41467-024-50855-3. Nat Commun. 2024. PMID: 39107277 Free PMC article.
Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial.
Verhaar BJH, Wijdeveld M, Wortelboer K, Rampanelli E, Levels JHM, Collard D, Cammenga M, Nageswaran V, Haghikia A, Landmesser U, Li XS, DiDonato JA, Hazen SL, Garrelds IM, Danser AHJ, van den Born BH, Nieuwdorp M, Muller M. Verhaar BJH, et al. Among authors: didonato ja. Hypertension. 2024 Oct;81(10):2124-2136. doi: 10.1161/HYPERTENSIONAHA.123.22437. Epub 2024 Jul 22. Hypertension. 2024. PMID: 39034917 Free PMC article. Clinical Trial.
110 results