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The C-terminal activating domain promotes pannexin 1 channel opening.
Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. Henze E, et al. Among authors: gelsleichter e. Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2411898121. doi: 10.1073/pnas.2411898121. Epub 2024 Dec 13. Proc Natl Acad Sci U S A. 2024. PMID: 39671183
ATP-release pannexin channels are gated by lysophospholipids.
Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T. Henze E, et al. Among authors: gelsleichter e. bioRxiv [Preprint]. 2024 Oct 26:2023.10.23.563601. doi: 10.1101/2023.10.23.563601. bioRxiv. 2024. PMID: 37961151 Free PMC article. Preprint.