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ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload.
Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG. Rypdal KB, et al. Among authors: apte ss. Commun Biol. 2022 Dec 20;5(1):1392. doi: 10.1038/s42003-022-04361-1. Commun Biol. 2022. PMID: 36539599 Free PMC article.
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.
Mead TJ, Bhutada S, Foulcer SJ, Peruzzi N, Nelson CM, Seifert DE, Larkin J, Tran-Lundmark K, Filmus J, Apte SS. Mead TJ, et al. Among authors: apte ss. Matrix Biol. 2024 Aug;131:1-16. doi: 10.1016/j.matbio.2024.05.003. Epub 2024 May 13. Matrix Biol. 2024. PMID: 38750698 Free PMC article.
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease.
de Groot R, Folgado PB, Yamamoto K, Martin DR, Koch CD, Debruin D, Blagg S, Minns AF, Bhutada S, Ahnström J, Larkin J, Aspberg A, Önnerfjord P, Apte SS, Santamaria S. de Groot R, et al. Among authors: apte ss. Matrix Biol. 2025 Feb;135:106-124. doi: 10.1016/j.matbio.2024.12.005. Epub 2024 Dec 11. Matrix Biol. 2025. PMID: 39672391 Free article.
Beyond the matrisome: New frontiers in ECM research.
Apte SS, Naba A. Apte SS, et al. Matrix Biol. 2023 Jan;115:133-138. doi: 10.1016/j.matbio.2022.12.003. Epub 2022 Dec 24. Matrix Biol. 2023. PMID: 36572230 No abstract available.
Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension.
van der Have O, Mead TJ, Westöö C, Peruzzi N, Mutgan AC, Norvik C, Bech M, Struglics A, Hoetzenecker K, Brunnström H, Westergren-Thorsson G, Kwapiszewska G, Apte SS, Tran-Lundmark K. van der Have O, et al. Among authors: apte ss. Pulm Circ. 2023 Feb 21;13(1):e12200. doi: 10.1002/pul2.12200. eCollection 2023 Jan. Pulm Circ. 2023. PMID: 36824691 Free PMC article.
Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown.
Bhutada S, Hoyle A, Piuzzi NS, Apte SS. Bhutada S, et al. Among authors: apte ss. Osteoarthritis Cartilage. 2025 Jan;33(1):116-127. doi: 10.1016/j.joca.2024.09.002. Epub 2024 Sep 16. Osteoarthritis Cartilage. 2025. PMID: 39293776 Free article.
205 results