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Page 1
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response.
Jaschke NP, Breining D, Hofmann M, Pählig S, Baschant U, Oertel R, Traikov S, Grinenko T, Saettini F, Biondi A, Stylianou M, Bringmann H, Zhang C, Yoshida TM, Weidner H, Poller WC, Swirski FK, Göbel A, Hofbauer LC, Rauner M, Scheiermann C, Wang A, Rachner TD. Jaschke NP, et al. Among authors: pahlig s. Immunity. 2024 Feb 13;57(2):364-378.e9. doi: 10.1016/j.immuni.2024.01.005. Epub 2024 Jan 31. Immunity. 2024. PMID: 38301651 Free article.
Rational engineering of glycosaminoglycan-based Dickkopf-1 scavengers to improve bone regeneration.
Ruiz-Gómez G, Salbach-Hirsch J, Dürig JN, Köhler L, Balamurugan K, Rother S, Heidig SL, Moeller S, Schnabelrauch M, Furesi G, Pählig S, Guillem-Gloria PM, Hofbauer C, Hintze V, Pisabarro MT, Rademann J, Hofbauer LC. Ruiz-Gómez G, et al. Among authors: pahlig s. Biomaterials. 2023 Jun;297:122105. doi: 10.1016/j.biomaterials.2023.122105. Epub 2023 Mar 31. Biomaterials. 2023. PMID: 37031548
Dickkopf1 fuels inflammatory cytokine responses.
Jaschke NP, Pählig S, Sinha A, Adolph TE, Colunga ML, Hofmann M, Wang A, Thiele S, Schwärzler J, Kleymann A, Gentzel M, Tilg H, Wielockx B, Hofbauer LC, Rauner M, Göbel A, Rachner TD. Jaschke NP, et al. Among authors: pahlig s. Commun Biol. 2022 Dec 20;5(1):1391. doi: 10.1038/s42003-022-04368-8. Commun Biol. 2022. PMID: 36539532 Free PMC article.
Circulating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19.
Jaschke NP, Funk AM, Jonas S, Riffel RM, Sinha A, Wang A, Pählig S, Hofmann M, Altmann H, Von Bonin S, Koch T, Spieth P, Tausche K, Akgün K, Rauner M, Kronstein-Wiedemann R, Odendahl M, Tonn T, Göbel A, Hofbauer LC, Rachner TD. Jaschke NP, et al. Among authors: pahlig s. J Clin Endocrinol Metab. 2022 Nov 25;107(12):3370-3377. doi: 10.1210/clinem/dgac514. J Clin Endocrinol Metab. 2022. PMID: 36071553 Free PMC article.
Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.
Müller ST, Pählig S, Merabet A, Abdelsamie AS, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW, Zierau O, Vollmer G. Müller ST, et al. Among authors: pahlig s. J Steroid Biochem Mol Biol. 2019 Sep;192:105405. doi: 10.1016/j.jsbmb.2019.105405. Epub 2019 Jun 8. J Steroid Biochem Mol Biol. 2019. PMID: 31185280