Zhang XY - Search Results

1

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.

Zheng ZG, Xu YY, Liu WP, Zhang Y, Zhang C, Liu HL, Zhang XY, Liu RZ, Zhang YP, Shi MY, Yang H, Li P. Zheng ZG, et al. Among authors: zhang yp, zhang c, zhang y, zhang xy. Cell Metab. 2023 Jan 3;35(1):101-117.e11. doi: 10.1016/j.cmet.2022.11.012. Epub 2022 Dec 15. Cell Metab. 2023. PMID: 36525963 Free article.

2

Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.

Min W, Wang Y, Shen H, Zheng M, Tong C, Shen H, Wang D, Zhu Y, Wang X, Xiao Y, Zhang XY, Yang P. Min W, et al. Among authors: zhang xy. Eur J Med Chem. 2024 Jan 15;264:116025. doi: 10.1016/j.ejmech.2023.116025. Epub 2023 Dec 5. Eur J Med Chem. 2024. PMID: 38086189

3

In vivo and in vitro evidence of the sex-dependent pharmacokinetics and disposition of G004, a potential hypoglycemic agent, in rats.

Hu L, Agbokponto JE, Li X, Ding L, Liu B, Zhong S, Zhang X, Du Y. Hu L, et al. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):187-202. doi: 10.1007/s13318-014-0196-7. Epub 2014 Apr 3. Eur J Drug Metab Pharmacokinet. 2015. PMID: 24696324

4

Discovery of Potent, Selective, and Orally Bioavailable DYRK2 Inhibitors for the Treatment of Prostate Cancer.

Yuan K, Xia F, Li Q, Zheng M, Shen H, Chen W, Yang H, Zhuang X, Zhang XY, Xiao Y, Yang P. Yuan K, et al. Among authors: zhang xy. J Med Chem. 2023 Dec 14;66(23):16235-16256. doi: 10.1021/acs.jmedchem.3c01626. Epub 2023 Nov 30. J Med Chem. 2023. PMID: 38033250

5

Synthesis and anti-tumor activity evaluation of 1H-pyrrolo[2,3-b]pyridine-2-carboxamide derivatives with phenyl sulfonamide groups as potent RSK2 inhibitors.

Zhang X, Zheng G, Gao S, Zhou F, Pan T, Shi Q, Li J, Zhang X, Huang Z, Quan X. Zhang X, et al. Chem Biol Drug Des. 2024 Jan;103(1):e14376. doi: 10.1111/cbdd.14376. Epub 2023 Oct 18. Chem Biol Drug Des. 2024. PMID: 37852922

6

Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities.

Zhang X, Wang W, Dong G, Song Y, Zhai X, Sheng C. Zhang X, et al. Bioorg Med Chem Lett. 2024 Sep 1;109:129838. doi: 10.1016/j.bmcl.2024.129838. Epub 2024 Jun 3. Bioorg Med Chem Lett. 2024. PMID: 38838918

7

Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.

Huang G, Cai Y, Ren M, Zhang X, Fu Y, Cheng R, Wang Y, Miao M, Zhu L, Yan T. Huang G, et al. J Adv Res. 2024 Sep 29:S2090-1232(24)00429-6. doi: 10.1016/j.jare.2024.09.027. Online ahead of print. J Adv Res. 2024. PMID: 39353532 Free article.

8

Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers.

Ren J, Quan X, Liu Y, Li J, Zhang X, Li Z, Zhang X. Ren J, et al. Bioorg Med Chem Lett. 2022 Dec 15;78:129046. doi: 10.1016/j.bmcl.2022.129046. Epub 2022 Nov 4. Bioorg Med Chem Lett. 2022. PMID: 36343904

9

Molecules inducing specific cyclin-dependent kinase degradation and their possible use in cancer therapy.

Zheng M, Zhang XY, Chen W, Xia F, Yang H, Yuan K, Yang P. Zheng M, et al. Among authors: zhang xy. Future Med Chem. 2024 Feb;16(4):369-388. doi: 10.4155/fmc-2023-0259. Epub 2024 Jan 30. Future Med Chem. 2024. PMID: 38288571 Review.

10

Cross-linked modifications of starches from colored highland barley and their characterizations, digestibility, and lipolysis inhibitory abilities in vitro.

Wang C, Fang S, Ren C, Huang C, Zhu H, Zhang X, Zhao J. Wang C, et al. Food Res Int. 2023 Dec;174(Pt 1):113493. doi: 10.1016/j.foodres.2023.113493. Epub 2023 Sep 23. Food Res Int. 2023. PMID: 37986410

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