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The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease.
Reinhart GA, Harrison PC, Lincoln K, Chen H, Sun P, Hill J, Qian HS, McHugh MC, Clifford H, Ng KJ, Wang H, Fowler D, Gueneva-Boucheva K, Brenneman JB, Bosanac T, Wong D, Fryer RM, Sarko C, Boustany-Kari CM, Pullen SS. Reinhart GA, et al. Among authors: fryer rm. J Pharmacol Exp Ther. 2023 Mar;384(3):382-392. doi: 10.1124/jpet.122.001423. Epub 2022 Dec 6. J Pharmacol Exp Ther. 2023. PMID: 36507845
Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
Sun P, Bartlett CS, Zheng C, Bigwarfe T, Grant JM, MacDougall M, Berger V, Kerr S, Qian HS, McHugh M, Chen H, Zhang X, Carpenter ML, Robinson HN, Miglietta J, Lamla T, Fryer RM. Sun P, et al. Among authors: fryer rm. J Pharmacol Exp Ther. 2022 Sep;382(3):266-276. doi: 10.1124/jpet.121.001067. Epub 2022 Jul 2. J Pharmacol Exp Ther. 2022. PMID: 35779860
Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357.
Harcken C, Csengery J, Turner M, Wu L, Liang S, Sibley R, Brunette S, Labadia M, Hoyt K, Wayne A, Wieckowski T, Davis G, Panzenbeck M, Souza D, Kugler S, Terenzio D, Collin D, Smith D, Fryer RM, Tseng YC, Hehn JP, Fletcher K, Hughes RO. Harcken C, et al. Among authors: fryer rm. ACS Med Chem Lett. 2021 Jan 5;12(1):143-154. doi: 10.1021/acsmedchemlett.0c00575. eCollection 2021 Jan 14. ACS Med Chem Lett. 2021. PMID: 33488976 Free PMC article.
A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat.
Boustany-Kari CM, Harrison PC, Chen H, Lincoln KA, Qian HS, Clifford H, Wang H, Zhang X, Gueneva-Boucheva K, Bosanac T, Wong D, Fryer RM, Richman JG, Sarko C, Pullen SS. Boustany-Kari CM, et al. Among authors: fryer rm. J Pharmacol Exp Ther. 2016 Mar;356(3):712-9. doi: 10.1124/jpet.115.230706. Epub 2016 Jan 4. J Pharmacol Exp Ther. 2016. PMID: 26729306
CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.
Lewis ND, Muthukumarana A, Fogal SE, Corradini L, Stefanopoulos DE, Adusumalli P, Pelletier J, Panzenbeck M, Berg K, Canfield M, Cook BN, Razavi H, Kuzmich D, Anderson S, Allard D, Harrison P, Grimaldi C, Souza D, Harcken C, Fryer RM, Modis LK, Brown ML. Lewis ND, et al. Among authors: fryer rm. PLoS One. 2014 Aug 29;9(8):e105883. doi: 10.1371/journal.pone.0105883. eCollection 2014. PLoS One. 2014. PMID: 25170619 Free PMC article.
60 results