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Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, Martínez JC, Lucena-Agell D, Prota AE, Bonato F, Bargsten K, Cornelus J, Giménez-Abián JF, Northcote P, Steinmetz MO, Kamimura S, Altmann KH, Paterson I, Gago F, Van der Eycken J, Díaz JF, Oliva MÁ. Estévez-Gallego J, et al. Among authors: raes o. Structure. 2023 Jan 5;31(1):88-99.e5. doi: 10.1016/j.str.2022.11.006. Epub 2022 Dec 2. Structure. 2023. PMID: 36462501 Free article.
Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties.
Vermeulen S, Ernst S, Blondeel E, Xia Z, Rappu P, Heino J, Dedeyne S, Denys H, Sys G, Gijsels S, Depypere H, Tummers P, Ceelen W, Craciun L, Demetter P, Raes O, Hendrix A, Van der Eycken J, De Wever O. Vermeulen S, et al. Among authors: raes o. Sci Rep. 2024 Dec 4;14(1):30188. doi: 10.1038/s41598-024-80672-z. Sci Rep. 2024. PMID: 39633082 Free PMC article.