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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: wilmes s. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
Mapping Determinants of Cytokine Signaling via Protein Engineering.
Gorby C, Martinez-Fabregas J, Wilmes S, Moraga I. Gorby C, et al. Among authors: wilmes s. Front Immunol. 2018 Sep 27;9:2143. doi: 10.3389/fimmu.2018.02143. eCollection 2018. Front Immunol. 2018. PMID: 30319612 Free PMC article. Review.
Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.
Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J. Richter D, et al. Among authors: wilmes s. Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976. Nat Commun. 2017. PMID: 28706306 Free PMC article.
47 results