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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: quesnel b. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
PD-1/PD-L1 binding studies using microscale thermophoresis.
Magnez R, Thiroux B, Taront S, Segaoula Z, Quesnel B, Thuru X. Magnez R, et al. Among authors: quesnel b. Sci Rep. 2017 Dec 15;7(1):17623. doi: 10.1038/s41598-017-17963-1. Sci Rep. 2017. PMID: 29247197 Free PMC article.
Acute Myeloid Leukemia: Is It T Time?
Ben Khoud M, Ingegnere T, Quesnel B, Mitra S, Brinster C. Ben Khoud M, et al. Among authors: quesnel b. Cancers (Basel). 2021 May 14;13(10):2385. doi: 10.3390/cancers13102385. Cancers (Basel). 2021. PMID: 34069204 Free PMC article. Review.
Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction.
Le Biannic R, Magnez R, Klupsch F, Leleu-Chavain N, Thiroux B, Tardy M, El Bouazzati H, Dezitter X, Renault N, Vergoten G, Bailly C, Quesnel B, Thuru X, Millet R. Le Biannic R, et al. Among authors: quesnel b. Eur J Med Chem. 2022 Jun 5;236:114343. doi: 10.1016/j.ejmech.2022.114343. Epub 2022 Apr 4. Eur J Med Chem. 2022. PMID: 35429911
228 results