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Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Tariq M, de Souza AH, Bensellam M, Chae H, Jaffredo M, Close AF, Deglasse JP, Santos LRB, Buemi A, Mourad NI, Wojtusciszyn A, Raoux M, Gilon P, Broca C, Jonas JC. Tariq M, et al. Among authors: close af. Diabetologia. 2023 Apr;66(4):709-723. doi: 10.1007/s00125-022-05842-y. Epub 2022 Dec 2. Diabetologia. 2023. PMID: 36459178