Newton AC - Search Results

1

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. Lordén G, et al. Among authors: newton ac. Nat Commun. 2022 Nov 23;13(1):7200. doi: 10.1038/s41467-022-34679-7. Nat Commun. 2022. PMID: 36418293 Free PMC article.

2

Regulation of protein kinase C.

Newton AC. Newton AC. Curr Opin Cell Biol. 1997 Apr;9(2):161-7. doi: 10.1016/s0955-0674(97)80058-0. Curr Opin Cell Biol. 1997. PMID: 9069266 Review.

3

Protein kinase C: poised to signal.

Newton AC. Newton AC. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. doi: 10.1152/ajpendo.00477.2009. Epub 2009 Nov 24. Am J Physiol Endocrinol Metab. 2010. PMID: 19934406 Free PMC article. Review.

4

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Antal CE, et al. Among authors: newton ac. Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22. Cell. 2015. PMID: 25619690 Free PMC article.

5

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Tsai LC, et al. Among authors: newton ac. J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17. J Biol Chem. 2015. PMID: 26187466 Free PMC article.

6

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease.

Newton AC, Tanzi RE, VanHook AM. Newton AC, et al. Sci Signal. 2016 May 10;9(427):pc11. doi: 10.1126/scisignal.aaf9436. Sci Signal. 2016. PMID: 27165779

7

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Alfonso SI, et al. Among authors: newton ac. Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209. Sci Signal. 2016. PMID: 27165780 Free PMC article.

8

Protein kinase C mechanisms that contribute to cardiac remodelling.

Newton AC, Antal CE, Steinberg SF. Newton AC, et al. Clin Sci (Lond). 2016 Sep 1;130(17):1499-510. doi: 10.1042/CS20160036. Clin Sci (Lond). 2016. PMID: 27433023 Free PMC article. Review.

9

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.

Newton AC, Brognard J. Newton AC, et al. Trends Pharmacol Sci. 2017 May;38(5):438-447. doi: 10.1016/j.tips.2017.02.002. Epub 2017 Mar 8. Trends Pharmacol Sci. 2017. PMID: 28283201 Free PMC article. Review.

10

Protein kinase C as a tumor suppressor.

Newton AC. Newton AC. Semin Cancer Biol. 2018 Feb;48:18-26. doi: 10.1016/j.semcancer.2017.04.017. Epub 2017 May 2. Semin Cancer Biol. 2018. PMID: 28476658 Free PMC article. Review.

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