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Page 1
Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential.
Flórez-Álvarez L, de Souza EE, Botosso VF, de Oliveira DBL, Ho PL, Taborda CP, Palmisano G, Capurro ML, Pinho JRR, Ferreira HL, Minoprio P, Arruda E, de Souza Ferreira LC, Wrenger C, Durigon EL. Flórez-Álvarez L, et al. Among authors: wrenger c. Front Microbiol. 2022 Oct 25;13:1040093. doi: 10.3389/fmicb.2022.1040093. eCollection 2022. Front Microbiol. 2022. PMID: 36386719 Free PMC article. Review.
Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19.
Silva-Santos Y, Pagni RL, Gamon THM, de Azevedo MSP, Bielavsky M, Darido MLG, de Oliveira DBL, de Souza EE, Wrenger C, Durigon EL, Luvizotto MCR, Ackerman HC, Marinho CRF, Epiphanio S, Carvalho LJM. Silva-Santos Y, et al. Among authors: wrenger c. Front Pharmacol. 2024 Jul 12;15:1414406. doi: 10.3389/fphar.2024.1414406. eCollection 2024. Front Pharmacol. 2024. PMID: 39070798 Free PMC article.
Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents.
da Silva Oliveira DD, Paz F, Brito NPF, Krüger A, Martinho ACC, Lapierre TJWJD, de Oliveira Souza F, Maltarollo VG, Kronenberger T, Mendes MS, Nonato MC, Pilau EJ, Wrenger C, Wunderlich G, Rezende Júnior CO. da Silva Oliveira DD, et al. Among authors: wrenger c. Eur J Med Chem. 2024 Sep 5;275:116621. doi: 10.1016/j.ejmech.2024.116621. Epub 2024 Jun 28. Eur J Med Chem. 2024. PMID: 38944935
Enhanced Immunogenicity and Protective Effects against SARS-CoV-2 Following Immunization with a Recombinant RBD-IgG Chimeric Protein.
Silva MO, Castro-Amarante MF, Venceslau-Carvalho AA, Almeida BDS, Daher IP, Souza-Silva GA, Yamamoto MM, Koike G, de Souza EE, Wrenger C, Ferreira LCS, Boscardin SB. Silva MO, et al. Among authors: wrenger c. Vaccines (Basel). 2024 Mar 27;12(4):356. doi: 10.3390/vaccines12040356. Vaccines (Basel). 2024. PMID: 38675739 Free PMC article.
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum.
Johannsen S, Gierse RM, Krüger A, Edwards RL, Nanna V, Fontana A, Zhu D, Masini T, de Carvalho LP, Poizat M, Kieftenbelt B, Hodge DM, Alvarez S, Bunt D, Lacour A, Shams A, Meissner KA, de Souza EE, Dröge M, van Vliet B, den Hartog J, Hutter MC, Held J, Odom John AR, Wrenger C, Hirsch AKH. Johannsen S, et al. Among authors: wrenger c. ACS Infect Dis. 2024 Mar 8;10(3):1000-1022. doi: 10.1021/acsinfecdis.3c00670. Epub 2024 Feb 17. ACS Infect Dis. 2024. PMID: 38367280 Free PMC article.
1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors.
Tavares MT, Krüger A, Yan SLR, Waitman KB, Gomes VM, de Oliveira DS, Paz F, Hilscher S, Schutkowski M, Sippl W, Ruiz C, Toledo MFZJ, Hassimotto NMA, Machado-Neto JA, Poso A, Cameron MD, Bannister TD, Palmisano G, Wrenger C, Kronenberger T, Parise-Filho R. Tavares MT, et al. Among authors: wrenger c. Sci Rep. 2023 Nov 29;13(1):21006. doi: 10.1038/s41598-023-47959-z. Sci Rep. 2023. PMID: 38030668 Free PMC article.
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Reinke PYA, de Souza EE, Günther S, Falke S, Lieske J, Ewert W, Loboda J, Herrmann A, Rahmani Mashhour A, Karničar K, Usenik A, Lindič N, Sekirnik A, Botosso VF, Santelli GMM, Kapronezai J, de Araújo MV, Silva-Pereira TT, Filho AFS, Tavares MS, Flórez-Álvarez L, de Oliveira DBL, Durigon EL, Giaretta PR, Heinemann MB, Hauser M, Seychell B, Böhler H, Rut W, Drag M, Beck T, Cox R, Chapman HN, Betzel C, Brehm W, Hinrichs W, Ebert G, Latham SL, Guimarães AMS, Turk D, Wrenger C, Meents A. Reinke PYA, et al. Among authors: wrenger c. Commun Biol. 2023 Oct 18;6(1):1058. doi: 10.1038/s42003-023-05317-9. Commun Biol. 2023. PMID: 37853179 Free PMC article.
Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice.
da Silva Santos Y, Gamon THM, de Azevedo MSP, Telezynski BL, de Souza EE, de Oliveira DBL, Dombrowski JG, Rosa-Fernandes L, Palmisano G, de Moura Carvalho LJ, Luvizotto MCR, Wrenger C, Covas DT, Curi R, Marinho CRF, Durigon EL, Epiphanio S. da Silva Santos Y, et al. Among authors: wrenger c. Viruses. 2023 Apr 19;15(4):999. doi: 10.3390/v15040999. Viruses. 2023. PMID: 37112979 Free PMC article.
108 results