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316 results

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Page 1
Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease.
Sanyal AJ, Van Natta ML, Clark J, Neuschwander-Tetri BA, Diehl A, Dasarathy S, Loomba R, Chalasani N, Kowdley K, Hameed B, Wilson LA, Yates KP, Belt P, Lazo M, Kleiner DE, Behling C, Tonascia J; NASH Clinical Research Network (CRN). Sanyal AJ, et al. Among authors: dasarathy s. N Engl J Med. 2021 Oct 21;385(17):1559-1569. doi: 10.1056/NEJMoa2029349. N Engl J Med. 2021. PMID: 34670043 Free PMC article.
The pyruvate dehydrogenase kinase inhibitor dichloroacetate mitigates alcohol-induced hepatic inflammation and metabolic disturbances in mice.
Wu J, Huang E, McMullen MR, Singh V, Mrdjen M, Bellar A, Wang L, Welch N, Dasarathy J, Dasarathy S, Streem D, Brown JM, Nagy LE. Wu J, et al. Among authors: dasarathy s. Hepatol Commun. 2024 Nov 29;8(12):e0547. doi: 10.1097/HC9.0000000000000547. eCollection 2024 Dec 1. Hepatol Commun. 2024. PMID: 39621302 Free PMC article.
Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis.
Overstreet AC, Burge M, Bellar A, McMullen M, Czarnecki D, Huang E, Pathak V, Finney C, Vij R, Dasarathy S, Dasarathy J, Streem D, Welch N, Rotroff D, Schmitt AM, Nagy LE, Messer JS. Overstreet AC, et al. Among authors: dasarathy s. medRxiv [Preprint]. 2024 Sep 6:2024.09.06.24313193. doi: 10.1101/2024.09.06.24313193. medRxiv. 2024. PMID: 39281760 Free PMC article. Preprint.
Aldehydes alter TGF-β signaling and induce obesity and cancer.
Yang X, Bhowmick K, Rao S, Xiang X, Ohshiro K, Amdur RL, Hassan MI, Mohammad T, Crandall K, Cifani P, Shetty K, Lyons SK, Merrill JR, Vegesna AK, John S, Latham PS, Crawford JM, Mishra B, Dasarathy S, Wang XW, Yu H, Wang Z, Huang H, Krainer AR, Mishra L. Yang X, et al. Among authors: dasarathy s. Cell Rep. 2024 Sep 24;43(9):114676. doi: 10.1016/j.celrep.2024.114676. Epub 2024 Aug 31. Cell Rep. 2024. PMID: 39217614 Free PMC article.
In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.
Nagesh PT, Cho Y, Zhuang Y, Babuta M, Ortega-Ribera M, Joshi R, Brezani V, Patel A, Datta AA, Brezani V, Hsieh YC, Ramos A, Mehta J, Copeland C, Kanata E, Jiang ZG, Vlachos I, Asara J; AlcHepNet Consortium; Szabo G. Nagesh PT, et al. Sci Transl Med. 2024 Aug 7;16(759):eadg1915. doi: 10.1126/scitranslmed.adg1915. Epub 2024 Aug 7. Sci Transl Med. 2024. PMID: 39110779
316 results