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How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC. Xu Y, et al. Among authors: lawrence mc. Structure. 2020 Jul 7;28(7):786-798.e6. doi: 10.1016/j.str.2020.05.002. Epub 2020 May 26. Structure. 2020. PMID: 32459985 Free PMC article.
Activation of the human insulin receptor by non-insulin-related peptides.
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martínez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC. Kirk NS, et al. Among authors: lawrence mc. Nat Commun. 2022 Sep 28;13(1):5695. doi: 10.1038/s41467-022-33315-8. Nat Commun. 2022. PMID: 36171189 Free PMC article.
The signalling conformation of the insulin receptor ectodomain.
Weis F, Menting JG, Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P, Langer T, Müller CW, Dreyer MK, Lawrence MC. Weis F, et al. Among authors: lawrence mc. Nat Commun. 2018 Oct 24;9(1):4420. doi: 10.1038/s41467-018-06826-6. Nat Commun. 2018. PMID: 30356040 Free PMC article.
How ligand binds to the type 1 insulin-like growth factor receptor.
Xu Y, Kong GK, Menting JG, Margetts MB, Delaine CA, Jenkin LM, Kiselyov VV, De Meyts P, Forbes BE, Lawrence MC. Xu Y, et al. Among authors: lawrence mc. Nat Commun. 2018 Feb 26;9(1):821. doi: 10.1038/s41467-018-03219-7. Nat Commun. 2018. PMID: 29483580 Free PMC article.
Structure of the insulin receptor ectodomain reveals a folded-over conformation.
McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW. McKern NM, et al. Among authors: lawrence mc. Nature. 2006 Sep 14;443(7108):218-21. doi: 10.1038/nature05106. Epub 2006 Sep 6. Nature. 2006. PMID: 16957736
Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Xiong X, et al. Among authors: lawrence mc. Nat Chem Biol. 2022 May;18(5):511-519. doi: 10.1038/s41589-022-00981-0. Epub 2022 Mar 14. Nat Chem Biol. 2022. PMID: 35289328 Free PMC article.
How insulin engages its primary binding site on the insulin receptor.
Menting JG, Whittaker J, Margetts MB, Whittaker LJ, Kong GK, Smith BJ, Watson CJ, Záková L, Kletvíková E, Jiráček J, Chan SJ, Steiner DF, Dodson GG, Brzozowski AM, Weiss MA, Ward CW, Lawrence MC. Menting JG, et al. Among authors: lawrence mc. Nature. 2013 Jan 10;493(7431):241-5. doi: 10.1038/nature11781. Nature. 2013. PMID: 23302862 Free PMC article.
134 results