Fynch S - Search Results

1

Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor.

Ge T, Phung AL, Jhala G, Trivedi P, Principe N, De George DJ, Pappas EG, Litwak S, Sanz-Villanueva L, Catterall T, Fynch S, Boon L, Kay TW, Chee J, Krishnamurthy B, Thomas HE. Ge T, et al. Among authors: fynch s. Clin Transl Immunology. 2022 Oct 30;11(11):e1425. doi: 10.1002/cti2.1425. eCollection 2022. Clin Transl Immunology. 2022. PMID: 36325490 Free PMC article.

2

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice.

Ge T, Jhala G, Fynch S, Akazawa S, Litwak S, Pappas EG, Catterall T, Vakil I, Long AJ, Olson LM, Krishnamurthy B, Kay TW, Thomas HE. Ge T, et al. Among authors: fynch s. Front Immunol. 2020 Dec 4;11:588543. doi: 10.3389/fimmu.2020.588543. eCollection 2020. Front Immunol. 2020. PMID: 33343569 Free PMC article.

3

Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.

Krishnamurthy B, Chee J, Jhala G, Fynch S, Graham KL, Santamaria P, Morahan G, Allison J, Izon D, Thomas HE, Kay TW. Krishnamurthy B, et al. Among authors: fynch s. Diabetes. 2012 Feb;61(2):425-35. doi: 10.2337/db11-0948. Epub 2011 Dec 21. Diabetes. 2012. PMID: 22190647 Free PMC article.

4

Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression.

Graham KL, Krishnamurthy B, Fynch S, Ayala-Perez R, Slattery RM, Santamaria P, Thomas HE, Kay TW. Graham KL, et al. Among authors: fynch s. Eur J Immunol. 2012 Jul;42(7):1717-22. doi: 10.1002/eji.201242435. Epub 2012 Jun 12. Eur J Immunol. 2012. PMID: 22585671 Free article.

5

Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.

Trivedi P, Graham KL, Krishnamurthy B, Fynch S, Slattery RM, Kay TW, Thomas HE. Trivedi P, et al. Among authors: fynch s. Immunol Cell Biol. 2016 Apr;94(4):334-41. doi: 10.1038/icb.2015.89. Epub 2015 Oct 8. Immunol Cell Biol. 2016. PMID: 26446877

6

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE. Trivedi PM, et al. Among authors: fynch s. Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14. Diabetes. 2017. PMID: 28292965

7

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice.

Trivedi PM, Fynch S, Kennedy LM, Chee J, Krishnamurthy B, O'Reilly LA, Strasser A, Kay TWH, Thomas HE. Trivedi PM, et al. Among authors: fynch s. Cell Death Discov. 2019 Sep 23;5:136. doi: 10.1038/s41420-019-0217-z. eCollection 2019. Cell Death Discov. 2019. PMID: 31552143 Free PMC article.

8

IL-21 regulates SOCS1 expression in autoreactive CD8⁺ T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice.

Sutherland APR, Graham KL, Papadimitriou M, Jhala G, Trivedi P, Catterall T, Fynch S, Kay TWH, Thomas HE. Sutherland APR, et al. Among authors: fynch s. Sci Rep. 2019 Oct 25;9(1):15302. doi: 10.1038/s41598-019-51636-5. Sci Rep. 2019. PMID: 31653894 Free PMC article.

9

IL-17F induces inflammation, dysfunction and cell death in mouse islets.

Catterall T, Fynch S, Kay TWH, Thomas HE, Sutherland APR. Catterall T, et al. Among authors: fynch s. Sci Rep. 2020 Aug 4;10(1):13077. doi: 10.1038/s41598-020-69805-2. Sci Rep. 2020. PMID: 32753746 Free PMC article.

10

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice.

Akazawa S, Mackin L, Jhala G, Fynch S, Catterall T, Selck C, Graham KL, Krishnamurthy B, Pappas EG, Kwong CJ, Sutherland APR, Kay TWH, Brodnicki TC, Thomas HE. Akazawa S, et al. Among authors: fynch s. Diabetologia. 2021 Apr;64(4):878-889. doi: 10.1007/s00125-020-05378-z. Epub 2021 Jan 23. Diabetologia. 2021. PMID: 33483762

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