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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells.
Elmelund E, Galsgaard KD, Johansen CD, Trammell SAJ, Bomholt AB, Winther-Sørensen M, Hunt JE, Sørensen CM, Kruse T, Lau JF, Grevengoed TJ, Holst JJ, Wewer Albrechtsen NJ. Elmelund E, et al. Among authors: hunt je. iScience. 2022 Oct 6;25(11):105296. doi: 10.1016/j.isci.2022.105296. eCollection 2022 Nov 18. iScience. 2022. PMID: 36325048 Free PMC article.
Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.
Galsgaard KD, Winther-Sørensen M, Ørskov C, Kissow H, Poulsen SS, Vilstrup H, Prehn C, Adamski J, Jepsen SL, Hartmann B, Hunt J, Charron MJ, Pedersen J, Wewer Albrechtsen NJ, Holst JJ. Galsgaard KD, et al. Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E93-E103. doi: 10.1152/ajpendo.00198.2017. Epub 2017 Oct 3. Am J Physiol Endocrinol Metab. 2018. PMID: 28978545 Free PMC article.
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Winther-Sørensen M, Galsgaard KD, Santos A, Trammell SAJ, Sulek K, Kuhre RE, Pedersen J, Andersen DB, Hassing AS, Dall M, Treebak JT, Gillum MP, Torekov SS, Windeløv JA, Hunt JE, Kjeldsen SAS, Jepsen SL, Vasilopoulou CG, Knop FK, Ørskov C, Werge MP, Bisgaard HC, Eriksen PL, Vilstrup H, Gluud LL, Holst JJ, Wewer Albrechtsen NJ. Winther-Sørensen M, et al. Among authors: hunt je. Mol Metab. 2020 Dec;42:101080. doi: 10.1016/j.molmet.2020.101080. Epub 2020 Sep 13. Mol Metab. 2020. PMID: 32937194 Free PMC article.
GLP-1 and Intestinal Diseases.
Hunt JE, Holst JJ, Jeppesen PB, Kissow H. Hunt JE, et al. Biomedicines. 2021 Apr 5;9(4):383. doi: 10.3390/biomedicines9040383. Biomedicines. 2021. PMID: 33916501 Free PMC article. Review.
106 results