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Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pf PI4KIIIβ).
Krishnan K, Ziniel P, Li H, Huang X, Hupalo D, Gombakomba N, Guerrero SM, Dotrang T, Lu X, Caridha D, Sternberg AR, Hughes E, Sun W, Bargieri DY, Roepe PD, Sciotti RJ, Wilkerson MD, Dalgard CL, Tawa GJ, Wang AQ, Xu X, Zheng W, Sanderson PE, Huang W, Williamson KC. Krishnan K, et al. Among authors: dotrang t. ACS Pharmacol Transl Sci. 2020 Sep 11;3(5):948-964. doi: 10.1021/acsptsci.0c00078. eCollection 2020 Oct 9. ACS Pharmacol Transl Sci. 2020. PMID: 33073193 Free PMC article.